The MRE11–RAD50–NBS1 complex conducts the orchestration of damage signaling and outcomes to stress in DNA replication and repair
Genomic instability in disease and its fidelity in health depend on the DNA damage
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …
Evolving SAXS versatility: solution X-ray scattering for macromolecular architecture, functional landscapes, and integrative structural biology
CA Brosey, JA Tainer - Current opinion in structural biology, 2019 - Elsevier
Highlights•SAXS captures architecture and dynamics to elucidate molecular
ensembles.•SAXS advances now probe key thermodynamic and kinetic properties of …
ensembles.•SAXS advances now probe key thermodynamic and kinetic properties of …
Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation
Structural resolution of protein interactions enables mechanistic and functional studies as
well as interpretation of disease variants. However, structural data is still missing for most …
well as interpretation of disease variants. However, structural data is still missing for most …
Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity
A Syed, F Filandr, J Patterson-Fortin… - Nucleic acids …, 2023 - academic.oup.com
Polymerase theta (Polθ) acts in DNA replication and repair, and its inhibition is synthetic
lethal in BRCA1 and BRCA2-deficient tumor cells. Novobiocin (NVB) is a first-in-class …
lethal in BRCA1 and BRCA2-deficient tumor cells. Novobiocin (NVB) is a first-in-class …
Function and molecular mechanism of the DNA damage response in immunity and cancer immunotherapy
The DNA damage response (DDR) is an organized network of multiple interwoven
components evolved to repair damaged DNA and maintain genome fidelity. Conceptually …
components evolved to repair damaged DNA and maintain genome fidelity. Conceptually …
Fructose-2, 6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntington's disease
A Chakraborty, SG Sreenivasmurthy, W Miller… - Proceedings of the …, 2024 - pnas.org
Huntington's disease (HD) and spinocerebellar ataxia type 3 (SCA3) are the two most
prevalent polyglutamine (polyQ) neurodegenerative diseases, caused by CAG (encoding …
prevalent polyglutamine (polyQ) neurodegenerative diseases, caused by CAG (encoding …
Mammalian DNA ligases; roles in maintaining genome integrity
The joining of breaks in the DNA phosphodiester backbone is essential for genome integrity.
Breaks are generated during normal processes such as DNA replication, cytosine …
Breaks are generated during normal processes such as DNA replication, cytosine …
Plugged into the Ku-DNA hub: The NHEJ network
P Frit, V Ropars, M Modesti, JB Charbonnier… - Progress in biophysics …, 2019 - Elsevier
In vertebrates, double-strand breaks in DNA are primarily repaired by Non-Homologous End-
Joining (NHEJ). The ring-shaped Ku heterodimer rapidly senses and threads onto broken …
Joining (NHEJ). The ring-shaped Ku heterodimer rapidly senses and threads onto broken …
Structure and mechanism in non-homologous end joining
A Vogt, Y He - DNA repair, 2023 - Elsevier
DNA double-stranded breaks (DSBs) are a particularly challenging form of DNA damage to
repair because the damaged DNA must not only undergo the chemical reactions …
repair because the damaged DNA must not only undergo the chemical reactions …
A Nucleophilicity‐Engineered DNA Ligation Blockade Nanoradiosensitizer Induces Irreversible DNA Damage to Overcome Cancer Radioresistance
H Yang, P Lin, B Zhang, F Li, D Ling - Advanced Materials, 2024 - Wiley Online Library
During fractionated radiotherapy, DNA damage repair intensifies in tumor cells, culminating
in cancer radioresistance and subsequent radiotherapy failure. Despite the recent …
in cancer radioresistance and subsequent radiotherapy failure. Despite the recent …