Therapeutic targets for cardiac fibrosis: from old school to next-gen
Cardiovascular diseases remain the leading cause of death worldwide, with pathological
fibrotic remodeling mediated by activated cardiac myofibroblasts representing a unifying …
fibrotic remodeling mediated by activated cardiac myofibroblasts representing a unifying …
Emerging epigenetic therapies of cardiac fibrosis and remodelling in heart failure: from basic mechanisms to early clinical development
Cardiovascular diseases and specifically heart failure (HF) impact global health and impose
a significant economic burden on society. Despite current advances in standard of care, the …
a significant economic burden on society. Despite current advances in standard of care, the …
Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure
Heart failure is a leading cause of cardiovascular morbidity and mortality. However, the
contribution of common genetic variation to heart failure risk has not been fully elucidated …
contribution of common genetic variation to heart failure risk has not been fully elucidated …
Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes
PP Shah, W Lv, JH Rhoades, A Poleshko, D Abbey… - Cell Stem Cell, 2021 - cell.com
Pathogenic mutations in LAMIN A/C (LMNA) cause abnormal nuclear structure and
laminopathies. These diseases have myriad tissue-specific phenotypes, including dilated …
laminopathies. These diseases have myriad tissue-specific phenotypes, including dilated …
Cardiac cell type–specific gene regulatory programs and disease risk association
Misregulated gene expression in human hearts can result in cardiovascular diseases that
are leading causes of mortality worldwide. However, the limited information on the genomic …
are leading causes of mortality worldwide. However, the limited information on the genomic …
Cardiac remodelling–Part 1: From cells and tissues to circulating biomarkers. A review from the Study Group on Biomarkers of the Heart Failure Association of the …
Cardiac remodelling refers to changes in left ventricular structure and function over time,
with a progressive deterioration that may lead to heart failure (HF) development (adverse …
with a progressive deterioration that may lead to heart failure (HF) development (adverse …
Rewiring of 3D chromatin topology orchestrates transcriptional reprogramming and the development of human dilated cardiomyopathy
Background: Transcriptional reconfiguration is central to heart failure, the most common
cause of which is dilated cardiomyopathy (DCM). The effect of 3-dimensional chromatin …
cause of which is dilated cardiomyopathy (DCM). The effect of 3-dimensional chromatin …
Genomic enhancers in cardiac development and disease
CG Anene-Nzelu, MCJ Lee, WLW Tan… - Nature Reviews …, 2022 - nature.com
Abstract The Human Genome Project marked a major milestone in the scientific community
as it unravelled the~ 3 billion bases that are central to crucial aspects of human life. Despite …
as it unravelled the~ 3 billion bases that are central to crucial aspects of human life. Despite …
Sex-dependent transcription of cardiac electrophysiology and links to acetylation modifiers based on the GTEx database
Development of safer drugs based on epigenetic modifiers, eg, histone deacetylase
inhibitors (HDACi), requires better understanding of their effects on cardiac …
inhibitors (HDACi), requires better understanding of their effects on cardiac …
Crosstalk between epitranscriptomic and epigenomic modifications and its implication in human diseases
Crosstalk between N 6-methyladenosine (m 6 A) and epigenomes is crucial for gene
regulation, but its regulatory directionality and disease significance remain unclear. Here …
regulation, but its regulatory directionality and disease significance remain unclear. Here …