An uncontrolled cell cycle is an obvious marker of tumor cells. The G1‑S phase is an
important restriction point in the normal cell cycle, but in cancer cells the restriction function …

E2F8 is a multifaceted transcription factor that plays a crucial role in mediating the hallmarks
of cancer, including sustaining proliferative signaling, resisting cell death, and activating …

E2Fs are a family of pivotal transcription factors. Accumulative evidence indicates that
aberrant expression or activation of E2Fs is a common phenomenon in malignances, and …

Prostate cancer (PCa) remains a leading cause of mortality among men in the United States
and Western Europe. The molecular mechanism of PCa pathogenesis has not been fully …

Abstract Background Telocytes (TCs) are newly identified interstitial cells that participate in
tissue protection and repair. The present study investigated the mechanisms underlying the …

Curcumin, a major yellow pigment and active component of turmeric, has anti-angiogenesis
properties. However, its molecular targets and mechanisms of curcumin effects on …

Abstract Anaplastic Thyroid Cancer (ATC) is the most aggressive and de-differentiated
subtype of thyroid cancer. Many studies hypothesized that ATC derives from Differentiated …

Introduction Tumorigenesis in breast cancers usually accompanied by the dysregulation of
transcription factors (TFs). Abnormal amplification of TFs leads aberrant expression of its …

The androgen receptor (AR) is the main driver in the development of castration‐resistant
prostate cancer, where the emergence of AR splice variants leads to treatment‐resistant …

Overexpression of the transcription factor, E2F8, has been associated with ovarian cancer.
Objectives of this study were to determine: 1) if E2F8 gene expression in granulosa cells …