Solid lipid nanoparticles and nanostructured lipid carriers: A review emphasizing on particle structure and drug release
A Gordillo-Galeano, CE Mora-Huertas - European Journal of Pharmaceutics …, 2018 - Elsevier
Colloidal systems based on lipids have attracted attention during the last two decades as a
delivery method of drugs that are poorly soluble in water. The investigations carried out have …
delivery method of drugs that are poorly soluble in water. The investigations carried out have …
PEGylation as a strategy for improving nanoparticle-based drug and gene delivery
Coating the surface of nanoparticles with polyethylene glycol (PEG), or “PEGylation”, is a
commonly used approach for improving the efficiency of drug and gene delivery to target …
commonly used approach for improving the efficiency of drug and gene delivery to target …
Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo
Achieving sustained drug delivery to mucosal surfaces is a major challenge due to the
presence of the protective mucus layer that serves to trap and rapidly remove foreign …
presence of the protective mucus layer that serves to trap and rapidly remove foreign …
Nanoparticle PEGylation for imaging and therapy
Nanoparticles are an essential component in the emerging field of nanomedical imaging
and therapy. When deployed in vivo, these materials are typically protected from the immune …
and therapy. When deployed in vivo, these materials are typically protected from the immune …
PEGylated PRINT nanoparticles: the impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics
JL Perry, KG Reuter, MP Kai, KP Herlihy, SW Jones… - Nano …, 2012 - ACS Publications
In this account, we varied PEGylation density on the surface of hydrogel PRINT
nanoparticles and systematically observed the effects on protein adsorption, macrophage …
nanoparticles and systematically observed the effects on protein adsorption, macrophage …
Lipid-based nanoparticles as pharmaceutical drug carriers: from concepts to clinic
In recent years, various nanotechnology platforms in the area of medical biology, including
both diagnostics and therapy, have gained remarkable attention. Moreover, research and …
both diagnostics and therapy, have gained remarkable attention. Moreover, research and …
[HTML][HTML] Recent progress of lipid nanoparticles-based lipophilic drug delivery: focus on surface modifications
Numerous drugs have emerged to treat various diseases, such as COVID-19, cancer, and
protect human health. Approximately 40% of them are lipophilic and are used for treating …
protect human health. Approximately 40% of them are lipophilic and are used for treating …
Assessment of PEG on polymeric particles surface, a key step in drug carrier translation
JM Rabanel, P Hildgen, X Banquy - Journal of controlled release, 2014 - Elsevier
Injectable drug nanocarriers have greatly benefited in their clinical development from the
addition of a superficial hydrophilic corona to improve their cargo pharmacokinetics. The …
addition of a superficial hydrophilic corona to improve their cargo pharmacokinetics. The …
Evading immune cell uptake and clearance requires PEG grafting at densities substantially exceeding the minimum for brush conformation
Q Yang, SW Jones, CL Parker… - Molecular …, 2014 - ACS Publications
Coating nanoparticles with polyethylene glycol (PEG), which reduces particle uptake and
clearance by immune cells, is routinely used to extend the circulation times of nanoparticle …
clearance by immune cells, is routinely used to extend the circulation times of nanoparticle …
Dense and dynamic polyethylene glycol shells cloak nanoparticles from uptake by liver endothelial cells for long blood circulation
Research into long-circulating nanoparticles has in the past focused on reducing their
clearance by macrophages. By engineering a hierarchical polyethylene glycol (PEG) …
clearance by macrophages. By engineering a hierarchical polyethylene glycol (PEG) …