Microenvironment-driven metabolic adaptations guiding CD8+ T cell anti-tumor immunity
J Park, PC Hsueh, Z Li, PC Ho - Immunity, 2023 - cell.com
The metabolic stress occurring in the tumor microenvironment (TME) hampers T cell anti-
tumor immunity by disturbing T cell metabolic and epigenetic programs. Recent studies are …
tumor immunity by disturbing T cell metabolic and epigenetic programs. Recent studies are …
[HTML][HTML] ABC transporters affects tumor immune microenvironment to regulate cancer immunotherapy and multidrug resistance
Multidrug resistance (MDR) is the phenomenon in which cancer cells simultaneously
develop resistance to a broad spectrum of structurally and mechanistically unrelated drugs …
develop resistance to a broad spectrum of structurally and mechanistically unrelated drugs …
Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments
Tissue-resident memory T cells (TRM cells) provide protective immunity, but the
contributions of specific tissue environments to TRM cell differentiation and homeostasis are …
contributions of specific tissue environments to TRM cell differentiation and homeostasis are …
The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues
L Kok, D Masopust, TN Schumacher - Nature Reviews Immunology, 2022 - nature.com
CD8+ tissue resident memory T cells (TRM cells) are essential for immune defence against
pathogens and malignancies, and the molecular processes that lead to TRM cell formation …
pathogens and malignancies, and the molecular processes that lead to TRM cell formation …
The immune cell landscape in kidneys of patients with lupus nephritis
A Arazi, DA Rao, CC Berthier, A Davidson, Y Liu… - Nature …, 2019 - nature.com
Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is
ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed …
ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed …
Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours
Tissue-resident memory CD8+ T (TRM) cells are found at common sites of pathogen
exposure, where they elicit rapid and robust protective immune responses,. However, the …
exposure, where they elicit rapid and robust protective immune responses,. However, the …
Understanding subset diversity in T cell memory
SC Jameson, D Masopust - Immunity, 2018 - cell.com
Considerable advances have been made in recent years in understanding the generation
and function of memory T cells. Memory T cells are typically parsed into discreet subsets …
and function of memory T cells. Memory T cells are typically parsed into discreet subsets …
The multifaceted role of tissue-resident memory T cells
Regionalized immune surveillance relies on the concerted efforts of diverse memory T cell
populations. Of these, tissue-resident memory T (TRM) cells are strategically positioned in …
populations. Of these, tissue-resident memory T (TRM) cells are strategically positioned in …
Divergent molecular networks program functionally distinct CD8+ skin-resident memory T cells
Skin-resident CD8+ T cells include distinct interferon-γ–producing [tissue-resident memory T
type 1 (TRM1)] and interleukin-17 (IL-17)–producing (TRM17) subsets that differentially …
type 1 (TRM1)] and interleukin-17 (IL-17)–producing (TRM17) subsets that differentially …
[HTML][HTML] Non-terminally exhausted tumor-resident memory HBV-specific T cell responses correlate with relapse-free survival in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) often develops following chronic hepatitis B virus (HBV)
infection and responds poorly to immune checkpoint blockade. Here, we examined the …
infection and responds poorly to immune checkpoint blockade. Here, we examined the …