The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing
malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating …

Heat shock proteins (HSPs) play cytoprotective activities under pathological conditions
through the initiation of protein folding, repair, refolding of misfolded peptides, and possible …

Purpose Autoantibody production is a characteristic of most autoimmune diseases including
rheumatoid arthritis (RA), but the stage of B-cell development at which B-cell tolerance is …

Almost instantaneously after the treatment of mouse SCCVII tumor cells with Photofrin-based
photodynamic therapy (PDT), a fraction (15-25%) of total cellular heat shock protein 70 …

The ability to mount a successful stress response in the face of injury is critical to the long‐
term viability of individual cells and to the organism in general. The stress response …

Angiogenesis promotes rejuvenation in multiple organs, including the skin. Heat shock
protein 90 (HSP90), hypoxia-inducible factor-1 alpha (HIF-1α), and vascular endothelial …

Written by Caleb Finch, one of the leading scientists of our time, The Biology of Human
Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans synthesizes …

Abstract The Injury Hypothesis, first published in 1994 and modified several times between
1996 and 2002, holds that the reactive oxygen species-mediated reperfusion injury to …

Abstract Background and Objectives The outcome of the treatment of solid tumors by
photodynamic therapy (PDT) is critically dependent on the contribution from the host. This …

Virus proliferation depends on the successful recruitment of host cellular components for
their own replication, protein synthesis, and virion assembly. In the course of virus particle …