Biological aging can be described as accumulative, prolonged metabolic stress and is the
major risk factor for cognitive decline and Alzheimer's disease (AD). Recently, we identified …

The flavoenzyme N-ribosyldihydronicotinamide (NRH): quinone oxidoreductase 2 (NQO2)
catalyzes two-electron reductions of quinones. NQO2 contributes to the metabolism of …

Dietary flavonoids stimulate autophagy and prevent liver dysfunction, but the upstream
signaling pathways triggered by these compounds are not well understood. Certain …

To survive in an ever-changing environment, animals must detect and learn salient
information. The anterior insular cortex (aIC) and medial prefrontal cortex (mPFC) are …

Increased evidence implies that melatonin may be a promising molecule for combating
COVID-19 due to its potent antioxidative, anti-inflammatory and immunoregulatory …

The formation of memory for a novel experience is a critical cognitive capacity. The ability to
form novel memories is sensitive to age-related pathologies and disease, to which …

Forming long-term memories is crucial for adaptive behavior and survival in changing
environments. The molecular consolidation processes which underlie the formation of these …

High‐frequency oscillatory activity in cognition‐related neural circuits during wakefulness
consistently induces the growth of dendritic spines and axonal terminals. Although these …

目的利用CRISPR/Cas9 基因编辑工具构建褪黑素3 型受体(MT 3 R/Nqo2) 基因敲除的SD 大鼠,
观察基因敲除后大鼠的睡眠/觉醒行为变化和EEG 能谱改变, 以探究褪黑素调控睡眠/觉醒的受体 …

Abstract Quinone reductases 1 and 2 (NQO1 and NQO2) are paralogous FAD-linked
enzymes found in all amniotes. NQO1 and NQO2 have similar structures and can both …