How bacterial pathogens coordinate appetite with virulence

ND Pokorzynski, EA Groisman - Microbiology and Molecular …, 2023 - Am Soc Microbiol
Cells adjust growth and metabolism to nutrient availability. Having access to a variety of
carbon sources during infection of their animal hosts, facultative intracellular pathogens …

Hundreds of antimicrobial peptides create a selective barrier for insect gut symbionts

J Lachat, G Lextrait, R Jouan… - Proceedings of the …, 2024 - National Acad Sciences
The spatial organization of gut microbiota is crucial for the functioning of the gut ecosystem,
although the mechanisms that organize gut bacterial communities in microhabitats are only …

The microbiota conditions a gut milieu that selects for wild-type Salmonella Typhimurium virulence

E Gül, E Bakkeren, G Salazar, Y Steiger… - PLoS …, 2023 - journals.plos.org
Salmonella Typhimurium elicits gut inflammation by the costly expression of HilD-controlled
virulence factors. This inflammation alleviates colonization resistance (CR) mediated by the …

High-throughput fitness experiments reveal specific vulnerabilities of human-adapted Salmonella during stress and infection

BX Wang, D Leshchiner, L Luo, M Tuncel, K Hokamp… - Nature Genetics, 2024 - nature.com
Salmonella enterica is comprised of genetically distinct 'serovars' that together provide an
intriguing model for exploring the genetic basis of pathogen evolution. Although the …

Physiological stress drives the emergence of a Salmonella subpopulation through ribosomal RNA regulation

CC Mattioli, K Eisner, A Rosenbaum, M Wang, A Amir… - Current Biology, 2023 - cell.com
Bacteria undergo cycles of growth and starvation to which they must adapt swiftly. One
important strategy for adjusting growth rates relies on ribosomal levels. Although high …

SPI-1 virulence gene expression modulates motility of Salmonella Typhimurium in a proton motive force- and adhesins-dependent manner

DO Saleh, JA Horstmann, M Giralt-Zúñiga… - PLoS …, 2023 - journals.plos.org
Both the bacterial flagellum and the evolutionary related injectisome encoded on the
Salmonella pathogenicity island 1 (SPI-1) play crucial roles during the infection cycle of …

Emergence of rapidly spreading antimicrobial-resistant Salmonella in traditional blood-based foods

T Yang, RA Wu-Chen, R Zhang, X Liao… - Food Quality and …, 2024 - academic.oup.com
Objectives This study aims to investigate the survival ability and risk of Salmonella isolated
from traditional blood-based food, using both phtnotypic and genotypic analysis. Materials …

Acinetobacter type VI secretion system comprises a non-canonical membrane complex

O Kandolo, Y Cherrak, I Filella-Merce… - PLoS …, 2023 - journals.plos.org
A. baumannii can rapidly acquire new resistance mechanisms and persist on abiotic
surface, enabling the colonization of asymptomatic human host. In Acinetobacter the type VI …

Combined oral vaccination with niche competition can generate sterilizing immunity against entero-pathogenic bacteria

V Lentsch, A Woller, C Moresi, SA Fattinger, S Aslani… - BioRXiv, 2022 - biorxiv.org
Widespread antimicrobial resistance generates an urgent need to develop better disease
prophylaxis for intestinal bacterial pathogens. While the first phase of infection with any …

Evolutionary trade-off between heat shock resistance, growth at high temperature, and virulence expression in Salmonella Typhimurium

D Berdejo, J Mortier, A Cambré, M Sobota… - Mbio, 2024 - Am Soc Microbiol
Understanding the evolutionary dynamics of foodborne pathogens throughout our food
production chain is of utmost importance. In this study, we reveal that Salmonella …