Biochemical and structural basis of sialic acid utilization by gut microbes
A Bell, E Severi, CD Owen, D Latousakis… - Journal of Biological …, 2023 - ASBMB
The human gastrointestinal (GI) tract harbors diverse microbial communities collectively
known as the gut microbiota that exert a profound impact on human health and disease. The …
known as the gut microbiota that exert a profound impact on human health and disease. The …
Elucidation of a sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut
Sialic acid (N-acetylneuraminic acid (Neu5Ac)) is commonly found in the terminal location of
colonic mucin glycans where it is a much-coveted nutrient for gut bacteria, including …
colonic mucin glycans where it is a much-coveted nutrient for gut bacteria, including …
Prokaryotic solute/sodium symporters: versatile functions and mechanisms of a transporter family
T Henriquez, L Wirtz, D Su, H Jung - International Journal of Molecular …, 2021 - mdpi.com
The solute/sodium symporter family (SSS family; TC 2. A. 21; SLC5) consists of integral
membrane proteins that use an existing sodium gradient to drive the uphill transport of …
membrane proteins that use an existing sodium gradient to drive the uphill transport of …
Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter
Tripartite ATP-independent periplasmic (TRAP) transporters are secondary-active
transporters that receive their substrates via a soluble-binding protein to move bioorganic …
transporters that receive their substrates via a soluble-binding protein to move bioorganic …
Structure and mechanism of a tripartite ATP-independent periplasmic TRAP transporter
In bacteria and archaea, tripartite ATP-independent periplasmic (TRAP) transporters uptake
essential nutrients. TRAP transporters receive their substrates via a secreted soluble …
essential nutrients. TRAP transporters receive their substrates via a secreted soluble …
Uncovering a novel molecular mechanism for scavenging sialic acids in bacteria
The human gut symbiont Ruminococcus gnavus scavenges host-derived N-
acetylneuraminic acid (Neu5Ac) from mucins by converting it to 2, 7-anhydro-Neu5Ac. We …
acetylneuraminic acid (Neu5Ac) from mucins by converting it to 2, 7-anhydro-Neu5Ac. We …
Multiple evolutionary origins reflect the importance of sialic acid transporters in the colonization potential of bacterial pathogens and commensals
Located at the tip of cell surface glycoconjugates, sialic acids are at the forefront of host–
microbe interactions and, being easily liberated by sialidase enzymes, are used as …
microbe interactions and, being easily liberated by sialidase enzymes, are used as …
Staphylococcus brunensis sp. nov. isolated from human clinical specimens with a staphylococcal cassette chromosome-related genomic island outside of the rlmH gene …
V Kovařovic, A Finstrlová, I Sedláček… - Microbiology …, 2023 - Am Soc Microbiol
Novel species of coagulase-negative staphylococci, which could serve as reservoirs of
virulence and antimicrobial resistance factors for opportunistic pathogens from the genus …
virulence and antimicrobial resistance factors for opportunistic pathogens from the genus …
Bacterial sialic acid catabolism at the host–microbe interface
J Kim, BS Kim - Journal of Microbiology, 2023 - Springer
Sialic acids consist of nine-carbon keto sugars that are commonly found at the terminal end
of mucins. This positional feature of sialic acids contributes to host cell interactions but is …
of mucins. This positional feature of sialic acids contributes to host cell interactions but is …
Multi-wavelength analytical ultracentrifugation as a tool to characterise protein–DNA interactions in solution
Understanding how proteins interact with DNA, and particularly the stoichiometry of a protein–
DNA complex, is key information needed to elucidate the biological role of the interaction, eg …
DNA complex, is key information needed to elucidate the biological role of the interaction, eg …