The activity of many vasomotor signaling pathways strongly depends on extracellular/
intracellular pH. Nitric oxide (NO) is one of the most important vasodilators produced by the …

Acid-base homeostasis maintains systemic arterial pH within a narrow range. Whereas the
normal range of pH for clinical laboratories is 7.35-7.45, in vivo pH is maintained within a …

Aims It has been known for more than a century that pH changes can alter vascular tone.
However, there is no consensus about the effects of pH changes on vascular response. In …

New Findings• What is the central question of this study? In human arteries involved in the
regulation of muscle blood flow, there is a lack of data about whether acidosis alters …

Metabolic acidosis has profound effects on vascular tone. This study investigated the in vivo
effects of acute metabolic acidosis (AMA) and chronic metabolic acidosis (CMA) on …

Here we have shown for the first time altered expression of the vascular smooth muscle
(VSM) KATP channel subunits in segments of the human internal mammary artery (HIMA) in …

Background Conventional peritoneal dialysis (PD) solutions elicit vasodilation, which is
implicated in the variable rate of solute transport during the dwell. The components causing …

Objective We hypothesized that CO2 and H+ stimulate capillaries and arterioles to produce
local and conducted vasodilations required to coordinate the distribution of blood flow to …

Sodium bicarbonate has been used in the treatment of different pathologies, such as
hyperkalemia, cardiac arrest, tricyclic antidepressant toxicity, aspirin toxicity, acute acidosis …

New Findings What is the central question of this study? We asked whether there are any
differences in responses to extracellular acidosis among arteries of different origin and …