Proteins are the main targets of most drugs; however, system-wide methods to monitor
protein activity and function are still underused in drug discovery. Novel biochemical …

Both ubiquitination and SUMOylation are dynamic post-translational modifications that
regulate thousands of target proteins to control virtually every cellular process …

Hepatic ischemia followed by reperfusion (I/R), a major clinical problem during liver surgical
procedures, can induce liver injury with severe cell death including ferroptosis which is …

Several ubiquitin chain types have remained unstudied, mainly because tools and
techniques to detect these posttranslational modifications are scarce. Linkage-specific …

Overproduced yeast ribosomal protein (RP) Rpl26 fails to assemble into ribosomes and is
degraded in the nucleus/nucleolus by a ubiquitin-proteasome system quality control …

Protein ubiquitylation is a widespread post-translational modification, regulating cellular
signalling with many outcomes, such as protein degradation, endocytosis, cell cycle …

Ornithine δ-aminotransferase (OAT, EC 2.6. 1.13) catalyzes the transfer of the δ-amino
group from ornithine (Orn) to α-ketoglutarate (aKG), yielding glutamate-5-semialdehyde and …

Ubiquitin (UB)-driven signaling systems permeate biology, and are often integrated with
other types of post-translational modifications (PTMs), including phosphorylation. Flux …

Summary mTORC1, the major homeostatic sensor and responder, regulates cell catabolism
mainly by targeting autophagy. Here, we show that mTORC1 directly controls …

Background and Aims In stomach, metaplasia can arise from differentiated chief cells that
become mitotic via paligenosis, a stepwise program. In paligenosis, mitosis initiation …