Sequencing-based methods and resources to study antimicrobial resistance

M Boolchandani, AW D'Souza, G Dantas - Nature Reviews Genetics, 2019 - nature.com
Antimicrobial resistance extracts high morbidity, mortality and economic costs yearly by
rendering bacteria immune to antibiotics. Identifying and understanding antimicrobial …

Genome-based prediction of bacterial antibiotic resistance

M Su, SW Satola, TD Read - Journal of clinical microbiology, 2019 - Am Soc Microbiol
Clinical microbiology has long relied on growing bacteria in culture to determine
antimicrobial susceptibility profiles, but the use of whole-genome sequencing for antibiotic …

Introducing the bacterial and viral bioinformatics resource center (BV-BRC): a resource combining PATRIC, IRD and ViPR

RD Olson, R Assaf, T Brettin, N Conrad… - Nucleic acids …, 2023 - academic.oup.com
Abstract The National Institute of Allergy and Infectious Diseases (NIAID) established the
Bioinformatics Resource Center (BRC) program to assist researchers with analyzing the …

The PATRIC Bioinformatics Resource Center: expanding data and analysis capabilities

JJ Davis, AR Wattam, RK Aziz, T Brettin… - Nucleic acids …, 2020 - academic.oup.com
Abstract The PathoSystems Resource Integration Center (PATRIC) is the bacterial
Bioinformatics Resource Center funded by the National Institute of Allergy and Infectious …

Machine learning for antimicrobial resistance prediction: current practice, limitations, and clinical perspective

JI Kim, F Maguire, KK Tsang, T Gouliouris… - Clinical microbiology …, 2022 - Am Soc Microbiol
Antimicrobial resistance (AMR) is a global health crisis that poses a great threat to modern
medicine. Effective prevention strategies are urgently required to slow the emergence and …

Antimicrobial resistance in rivers: a review of the genes detected and new challenges

P Grenni - Environmental Toxicology and Chemistry, 2022 - Wiley Online Library
River ecosystems are very important parts of the water cycle and an excellent habitat, food,
and drinking water source for many organisms, including humans. Antibiotics are emerging …

Using Machine Learning To Predict Antimicrobial MICs and Associated Genomic Features for Nontyphoidal Salmonella

M Nguyen, SW Long, PF McDermott… - Journal of clinical …, 2019 - Am Soc Microbiol
Nontyphoidal Salmonella species are the leading bacterial cause of foodborne disease in
the United States. Whole-genome sequences and paired antimicrobial susceptibility data …

Prediction of antibiotic resistance in Escherichia coli from large-scale pan-genome data

D Moradigaravand, M Palm, A Farewell… - PLoS computational …, 2018 - journals.plos.org
The emergence of microbial antibiotic resistance is a global health threat. In clinical settings,
the key to controlling spread of resistant strains is accurate and rapid detection. As …

Developing an in silico minimum inhibitory concentration panel test for Klebsiella pneumoniae

M Nguyen, T Brettin, SW Long, JM Musser, RJ Olsen… - Scientific reports, 2018 - nature.com
Antimicrobial resistant infections are a serious public health threat worldwide. Whole
genome sequencing approaches to rapidly identify pathogens and predict antibiotic …

Viruses as key reservoirs of antibiotic resistance genes in the environment

D Debroas, C Siguret - The ISME journal, 2019 - academic.oup.com
Antibiotic resistance is a rapidly growing health care problem globally and causes many
illnesses and deaths. Bacteria can acquire antibiotic resistance genes (ARGs) by horizontal …