Genetic factors contribute importantly to the risk of coronary artery disease (CAD), and in the
past decade, there has been major progress in this area. The tools applied include genome …

An exciting new era has dawned for the prevention and management of coronary artery
disease (CAD) utilizing genetic risk variants. The recent identification of over 60 …

Coronary artery disease (CAD) is a pandemic disease that is highly preventable as shown
by secondary prevention. Primary prevention is preferred knowing that 50% of the …

There is almost no data on the genetics of acute coronary syndromes, so this review
discusses primarily the 50 genetic risk variants associated with coronary artery disease that …

Genome-wide association studies (GWAS) have greatly expanded our understanding of the
genetic architecture of cardiovascular diseases in the past decade. They have revealed …

Background Lipoprotein (a) concentrations in plasma are associated with cardiovascular
risk in the general population. Whether lipoprotein (a) concentrations or LPA genetic …

Objective Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a circulating protein that
promotes degradation of the low density lipoprotein (LDL) receptor. Mutations that block …

Background Data are limited on genome-wide association studies (GWAS) for incident
coronary heart disease (CHD). Moreover, it is not known whether genetic variants identified …

Atherosclerosis research has classically followed 2 intertwining lines of investigation
concerning atherosclerosis as a local process (the “high-risk plaque”) and as a systemic …

Objective—A genetic risk score (GRS) for coronary artery disease has recently been shown
to be independent of family history (FHx) in predicting future cardiovascular events. We …