T cell dynamics in HIV-1 infection

DC Douek, LJ Picker, RA Koup - Annual review of immunology, 2003 - annualreviews.org
▪ Abstract In the absence of antiretroviral treatment, HIV-1 establishes a chronic, progressive
infection of the human immune system that invariably, over the course of years, leads to its …

T cell depletion in HIV-1 infection: how CD4+ T cells go out of stock

MD Hazenberg, D Hamann, H Schuitemaker… - Nature …, 2000 - nature.com
HIV-1 infection is characterized by a gradual loss of CD4+ T cells and progressive immune
deficiency that leads to opportunistic infections, otherwise rare malignancies and ultimately …

[图书][B] WHO case definitions of HIV for surveillance and revised clinical staging and immunological classification of HIV-related disease in adults and children

World Health Organization - 2007 - apps.who.int
With a view to facilitating the scaling up of access to antiretroviral therapy, and in line with a
public health approachi, this publication outlines recent revisions WHO has made to case …

Lymphocyte subsets in healthy children from birth through 18 years of age: the Pediatric AIDS Clinical Trials Group P1009 study

WT Shearer, HM Rosenblatt, RS Gelman… - Journal of Allergy and …, 2003 - Elsevier
BACKGROUND: Peripheral blood lymphocyte subsets need to be determined in a large,
urban, minority-predominant cohort of healthy children to serve as suitable control subjects …

Reduction in mortality with availability of antiretroviral therapy for children with perinatal HIV-1 infection

M de Martino, PA Tovo, M Balducci, L Galli, C Gabiano… - Jama, 2000 - jamanetwork.com
ContextSince the introduction of combined antiretroviral therapy, mortality rates in adults
with human immunodeficiency virus type 1 (HIV-1) infection have decreased. However, little …

Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function

L Teixeira, H Valdez, JM McCune, RA Koup, AD Badley… - Aids, 2001 - journals.lww.com
Objective To characterize immune phenotype and thymic function in HIV-1-infected adults
with excellent virologic and poor immunologic responses to highly active antiretroviral …

The extent of HIV-1-related immunodeficiency and age predict the long-term CD4 T lymphocyte response to potent antiretroviral therapy

GR Kaufmann, M Bloch, R Finlayson, J Zaunders… - Aids, 2002 - journals.lww.com
The extent of HIV-1-related immunodeficiency and age predict... : AIDS The extent of HIV-1-related
immunodeficiency and age predict the long-term CD4 T lymphocyte response to potent …

Efficacy of highly active antiretroviral therapy in HIV-1 infected children

AMC van Rossum, PLA Fraaij… - The Lancet Infectious …, 2002 - thelancet.com
Although the reduction in HIV-1-related deaths with highly active antiretroviral therapy
(HAART) is similar in adults and children, the extent of the changes in two important …

Indinavir: a review of its use in the management of HIV infection

GL Plosker, S Noble - Drugs, 1999 - Springer
Indinavir is a protease inhibitor used in the treatment of patients with HIV infection.
Combination antiretroviral therapy with indinavir plus 2 nucleoside reverse transcriptase …

Rapid restoration of CD4 T cell subsets in subjects receiving antiretroviral therapy during primary HIV-1 infection

GR Kaufmann, JJ Zaunders, P Cunningham… - Aids, 2000 - journals.lww.com
Objective To compare the effect of highly active antiretroviral therapy on immune
reconstitution in subjects with acute and chronic HIV-1 infection. Design Prospective study …