Indigenous emergence and spread of kelch13 C469Y artemisinin-resistant Plasmodium falciparum in Uganda
P Awor, R Coppée, N Khim… - Antimicrobial Agents …, 2024 - journals.asm.org
Artemisinin-based combination therapies (ACTs) were introduced as the standard of care for
uncomplicated malaria in Africa almost two decades ago. Recent studies in East Africa have …
uncomplicated malaria in Africa almost two decades ago. Recent studies in East Africa have …
A retrospective analysis of P. falciparum drug resistance markers detects an early (2016/17) high prevalence of the k13 C469Y mutation in asymptomatic infections in …
The emergence of drug-resistant Plasmodium falciparum parasites in sub-Saharan Africa
will substantially challenge malaria control. Here, we evaluated the frequency of common …
will substantially challenge malaria control. Here, we evaluated the frequency of common …
A Plasmodium falciparum genetic cross reveals the contributions of pfcrt and plasmepsin II/III to piperaquine drug resistance
Piperaquine (PPQ) is widely used in combination with dihydroartemisinin as a first-line
treatment against malaria. Multiple genetic drivers of PPQ resistance have been reported …
treatment against malaria. Multiple genetic drivers of PPQ resistance have been reported …
Ex vivo drug susceptibility and resistance mediating genetic polymorphisms of Plasmodium falciparum in Bobo-Dioulasso, Burkina Faso
AF Somé, MD Conrad, Z Kabré, A Fofana… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
Malaria remains a leading cause of morbidity and mortality in Burkina Faso, which utilizes
artemether–lumefantrine as the principal therapy to treat uncomplicated malaria and …
artemether–lumefantrine as the principal therapy to treat uncomplicated malaria and …
Susceptibility of ugandan Plasmodium falciparum isolates to the antimalarial drug pipeline
O Kreutzfeld, PK Tumwebaze, M Okitwi… - Microbiology …, 2023 - Am Soc Microbiol
Malaria, especially Plasmodium falciparum infection, remains an enormous problem, and its
treatment and control are seriously challenged by drug resistance. New antimalarial drugs …
treatment and control are seriously challenged by drug resistance. New antimalarial drugs …
The extended recovery ring-stage survival assay is a scalable alternative for artemisinin susceptibility phenotyping of fresh Plasmodium falciparum isolates
M Okitwi, DA Shoue, LA Checkley… - Antimicrobial Agents …, 2024 - journals.asm.org
Artemisinin partial resistance (ART-R) has emerged in eastern Africa, necessitating regular
surveillance of susceptibility of Plasmodium falciparum to artemisinins. The microscopy …
surveillance of susceptibility of Plasmodium falciparum to artemisinins. The microscopy …
Enhanced cell stress response and protein degradation capacity underlie artemisinin resistance in Plasmodium falciparum
MR Rosenthal, S Vijayrajratnam, TM Firestone, CL Ng - Msphere, 2024 - journals.asm.org
Malaria remains a global health burden, killing over half a million people each year.
Decreased therapeutic efficacy to artemisinin, the most efficacious antimalarial, has been …
Decreased therapeutic efficacy to artemisinin, the most efficacious antimalarial, has been …
[PDF][PDF] Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline
A Smith, H Kano, SL Nsobya, B Blasco, M Duffey… - 2023 - media.malariaworld.org
Malaria, especially Plasmodium falciparum infection, remains an enormous problem, and its
treatment and control are seriously challenged by drug resistance. New antimalarial drugs …
treatment and control are seriously challenged by drug resistance. New antimalarial drugs …