The dominant paradigm in drug discovery is to design ligands with maximum selectivity to
act on individual drug targets. With the target-based approach, many new chemical entities …

Histone deacetylases (HDACs) are a class of enzymes that remove acetyl from the ε-N-
acetyl lysine of histones, allowing histones to wrap DNA more tightly. HDACs play an …

Histone deacetylases, as a new class of anticancer targets, could maintain homeostasis by
catalyzing histone deacetylation and play important roles in regulating the expression of …

Recently, molecular hybridization paradigm became an interesting and smart way to defeat
the multifaceted cancer disease by a single molecular entity that acts via several …

Sorghum bicolor plant has a high abundance of 3-deoxyanthocyanins, flavonoids and other
polyphenol compounds that have been shown to offer numerous health benefits …

Herein, we report distal amidoketone and nitrogen-functionalized ketone syntheses from
alcohols and N–H nucleophiles enabled by hypervalent iodine dimethyl benziodoxoles …

Abstract 'Epigenetic'regulation of genes via post-translational modulation of proteins is the
current mainstay approach for the disease therapies, particularly explored in the Histone …

Therapy of acute myeloid leukemia (AML) is unsatisfactory. Histone deacetylase inhibitors
(HDACi) are active against leukemic cells in vitro and in vivo. Clinical data suggest further …

Multitarget inhibitors design has generated great interest in cancer treatment. Based on the
synergistic effects of topoisomerase and histone deacetylase inhibitors, we designed and …

Histone deacetylases (HDACs) are attractive therapeutic targets due to their involvement in
a variety of human diseases including cancer. All FDA-approved HDAC-targeting drugs are …