Quinoxaline 1,4-di-N-Oxides: Biological Activities and Mechanisms of Actions

G Cheng, W Sa, C Cao, L Guo, H Hao, Z Liu… - Frontiers in …, 2016 - frontiersin.org
Quinoxaline 1, 4-di-N-oxides (QdNOs) have manifold biological properties, including
antimicrobial, antitumoral, antitrypanosomal and antiinflammatory/antioxidant activities …

Present status of quinoxaline motifs: Excellent pathfinders in therapeutic medicine

OO Ajani - European journal of medicinal chemistry, 2014 - Elsevier
Quinoxalines belong to a class of excellent heterocyclic scaffolds owing to their wide
biological properties and diverse therapeutic applications in medicinal research. They are …

Quinoxaline 1, 4-dioxides: advances in chemistry and chemotherapeutic drug development

GI Buravchenko, AE Shchekotikhin - Pharmaceuticals, 2023 - mdpi.com
N-Oxides of heterocyclic compounds are the focus of medical chemistry due to their diverse
biological properties. The high reactivity and tendency to undergo various rearrangements …

In Vitro and In Silico Analysis of New n-Butyl and Isobutyl Quinoxaline-7-carboxylate 1,4-di-N-oxide Derivatives against Trypanosoma cruzi as Trypanothione …

A González-González, O Sánchez-Sánchez… - International Journal of …, 2022 - mdpi.com
American trypanosomiasis is a worldwide health problem that requires attention due to
ineffective treatment options. We evaluated n-butyl and isobutyl quinoxaline-7-carboxylate 1 …

An overview of mucosa-associated protozoa: challenges in chemotherapy and future perspectives

HLC Santos, KM Rebello - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
Parasitic infections caused by protozoans that infect the mucosal surfaces are widely
neglected worldwide. Collectively, Entamoeba histolytica, Giardia lamblia, Cryptosporidium …

Anti-Trypanosoma cruzi and anti-leishmanial activity by quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives

JC Villalobos-Rocha, L Sánchez-Torres… - Parasitology …, 2014 - Springer
In this work, a novel series of ethyl and methyl quinoxaline-7-carboxylate 1, 4-di-N-oxide
derivatives were evaluated in vitro on Trypanosoma cruzi trypomastigotes and Leishmania …

Trypanocidal Activity of Quinoxaline 1,4 Di-N-oxide Derivatives as Trypanothione Reductase Inhibitors

KF Chacón-Vargas, B Nogueda-Torres… - Molecules, 2017 - mdpi.com
Chagas disease or American trypanosomiasis is a worldwide public health problem. In this
work, we evaluated 26 new propyl and isopropyl quinoxaline-7-carboxylate 1, 4-di-N-oxide …

An appraisal on synthetic and pharmaceutical perspectives of quinoxaline 1,4‐di‐N‐oxide scaffold

N Agrawal, A Bhardwaj - Chemical Biology & Drug Design, 2022 - Wiley Online Library
Abstract Quinoxaline 1, 4‐di‐N‐oxides (QdNOs) exhibit multifaceted biological properties,
wherein antimicrobial, anticancer, antitrypanosomal, and anti‐inflammatory properties are …

Current status of quinoxaline and quinoxaline 1,4‐di‐N‐oxides derivatives as potential antiparasitic agents

J Soto‐Sánchez, JD Ospina‐Villa - Chemical Biology & Drug …, 2021 - Wiley Online Library
Parasitic diseases are a public health problem, especially in developing countries where
millions of people are affected every year. Current treatments have several drawbacks …

Parasitic diarrheal disease: drug development and targets

A Azam, MN Peerzada, K Ahmad - Frontiers in microbiology, 2015 - frontiersin.org
Diarrhea is the manifestation of gastrointestinal infection and is one of the major causes of
mortality and morbidity specifically among the children of less than 5 years age worldwide …