Despite substantial scientific progress over the past two decades, malaria remains a
worldwide burden that causes hundreds of thousands of deaths every year. New, affordable …

The chemistry of heterocyclic compounds has traditionally been and remains a bright area of
chemical science in Russia. This is due to the fact that many heterocycles find the widest …

The resistance of malaria parasites to existing drugs carries on growing and progressively
limiting our ability to manage this severe disease and finally lead to a massive global health …

Over the past decade, there has been a transformation in the portfolio of medicines to
combat malaria. New fixed-dose artemisinin combination therapy is available, with four …

Highlights•Artemisinin is a pro-drug that is activated by heme or iron.•Hemoglobin
degradation generates an artemisinin activator.•Parasite killing requires exposure to an …

Artemisinin combination therapies (ACTs) have been used as the first‐line treatments
against Plasmodium falciparum malaria for decades. Recent advances in chemical …

Cyclic peroxides such as the plant-derived 1, 2, 4-trioxane artemisinin and its derivatives are
short-lived, rapidly-acting antimalarials that are now usually combined with standard long …

The present review describes the current status of synthetic five and six-membered cyclic
peroxides such as 1, 2-dioxolanes, 1, 2, 4-trioxolanes (ozonides), 1, 2-dioxanes, 1, 2 …

Malaria is a life-threatening infectious disease caused by protozoal parasites belonging to
the genus Plasmodium. It caused an estimated 405,000 deaths and 228 million malaria …

The isolation of artemisinin from the traditional medicinal herb qīng hāo (Artemisia annua),
its characterization as a peroxide and preparation of the derivatives dihydroartemisinin …