Reprogramming the immunosuppressive tumor microenvironment by modulating
macrophages holds great promise in tumor immunotherapy. As a class of professional …

Efferocytosis is the effective clearance of apoptotic cells by professional and non-
professional phagocytes. The process is mechanically different from other forms of …

The poor progress of immunotherapy on osteosarcoma patients requires deeper delineation
of immune tolerance mechanisms in the osteosarcoma microenvironment and a new …

Creating cellular homeostasis within a defined tissue typically relates to the processes of
apoptosis and efferocytosis. A great example here is cell debris that must be removed to …

Macrophages, as pivotal cells within the tumour microenvironment, significantly influence
the impact of and reactions to treatments for solid tumours. The rapid evolution of …

The immunologic effects of chemotherapy-induced tumor cell death are not completely
understood. Accumulating evidence suggests that phagocytic clearance of apoptotic tumor …

Post-surgical efferocytosis of tumor associated macrophages (TAMs) originates an
immunosuppressive tumor microenvironment and facilitates abscopal metastasis of residual …

Background Efferocytosis is a biological process in which phagocytes remove apoptotic
cells and vesicles from tissues. This process is initiated by the release of inflammatory …

In recent years, we have realized that extracellular vesicles (EVs) play a critical role in
regulating the intercellular communication between tumor and immune cells in the tumor …

The clearance of apoptotic cells by efferocytes such as macrophages and dendritic cells is
termed as “efferocytosis”, it plays critical roles in maintaining tissue homeostasis in …