It has been amply constated that sugar ligand multivalency increases lectin-binding avidities
dramatically, thereby modulating the capacity of carbohydrates to participate in …

A bunch of keys, one lock: The multivalent effect in glycosidase inhibition is a new, rapidly
emerging area with exciting potential and scope. This review presents a description of the …

Lysosomal storage disorders (LSDs) are often caused by mutations that destabilize native
folding and impair the trafficking of enzymes, leading to premature endoplasmic reticulum …

Nucleoside analogs are commonly used in the treatment of cancer and viral infections. Their
syntheses benefit from decades of research but are often protracted, unamenable to …

Glycosidases are key enzymes in metabolism, pathogenic/antipathogenic mechanisms and
normal cellular functions. Recently, a novel approach for glycosidase inhibition that conveys …

Concerted functioning of lectins and carbohydrate‐processing enzymes, mainly
glycosidases, is essential in maintaining life. It was commonly assumed that the …

Glycosidases are extremely widespread enzymes responsible for the cleavage of glycosidic
bonds in glycoconjugates found in living organisms. Although it was well-known that the …

The aberrant presentation of carbohydrates has been linked to a number of diseases, such
as cancer metastasis and immune dysregulation. These altered glycan structures represent …

Novel synthetic methods published since 2005 affording carbohydrates containing sulfur
atom (s) are reviewed. The review is divided to subchapters based on the position of sulfur …

The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate
determinant. The use of glycopeptides that incorporate this structure has become a …