Abstract The 2018 Nobel Prize in Physiology or Medicine was awarded to pioneers in the
field of cancer immunotherapy, as the utility of leveraging a patient's coordinated and …

Mobilizing antitumour immunity through vaccination potentially constitutes a powerful
anticancer strategy but has not yet provided robust clinical benefits in large patient …

The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

In single-cell analysis, cellular activity and parameters are assayed on an individual, rather
than population-average basis. Essential to observing the activity of these cells over time is …

In vitro 3D models are advanced biological tools that have been established to overcome
the shortcomings of oversimplified 2D cultures and mouse models. Various in vitro 3D …

Recent advances in cellular profiling have demonstrated substantial heterogeneity in the
behaviour of cells once deemed'identical', challenging fundamental notions of …

While vat photopolymerization has many advantages over soft lithography in fabricating
microfluidic devices, including efficiency and shape complexity, it has difficulty achieving …

Bridging the gap between findings in preclinical 2D cell culture models and in vivo tissue
cultures has been challenging; the simple microenvironment of 2D monolayer culture …

Single-cell RNA sequencing (scRNA-seq) approaches have transformed our ability to
resolve cellular properties across systems, but are currently tailored toward large cell inputs …

Adoptive T cell transfer, in particular TCR T cell therapy, holds great promise for cancer
immunotherapy with encouraging clinical results. However, finding the right TCR T cell clone …