The vast majority of research on nuclear factor κB (NF‐κB) signaling in the past 25 years has
focused on its roles in normal and disease‐related processes in vertebrates, especially mice …

Optical biosensor technology continues to be the method of choice for label‐free, real‐time
interaction analysis. But when it comes to improving the quality of the biosensor literature …

Summary The Rab GTPases recruit peripheral membrane proteins to intracellular
organelles. These Rab effectors typically mediate the motility of organelles and vesicles and …

Almost all animals contain mitochondria of maternal origin only, but the exact mechanisms
underlying this phenomenon are still vague. We investigated the fate of Drosophila paternal …

Subcellular location and activation of Tank Binding Kinase 1 (TBK1) govern precise
progression through mitosis. Either loss of activated TBK1 or its sequestration from the …

The IκB kinases IKKα and IKKβ and the IKK-related kinases TANK-binding kinase 1 (TBK1)
and IKKε are the master regulators of the NF-κB signaling pathway. Although this pathway …

Immune deficiency (IMD) pathway, one of the most essential pattern recognition receptor
signaling pathways, plays vital roles in innate immune responses to eliminate pathogen …

The scaffold protein PAR3 and the kinase PAR1 are essential proteins that control cell
polarity. Their precise opposite localisations define plasma membrane domains with specific …

Toll and IMD pathways regulate antimicrobial innate immune responses in insect model
systems. The transcriptional activation of antimicrobial peptides (AMPs) confers humoral …

IKK (inhibitor of NF-κB kinase) is the critical regulator for NF-κB (nuclear factor-κB) pathway
against pathogenic invasion in vertebrates or invertebrates. However, the IKK from crab …