SPARC is a multifunctional glycoprotein that belongs to the matricellular group of proteins. It
modulates cellular interaction with the extracellular matrix (ECM) by its binding to structural …

Ovarian adenocarcinoma is characterized by a late detection, dissemination of cancer cells
into the whole peritoneum, and the frequent acquisition of chemoresistance. If these …

Tumor growth is essentially the result of an evolving cross-talk between malignant and
surrounding stromal cells (fibroblasts, endothelial cells and inflammatory cells). This …

Physical activity has been found to aid the maintenance of health in the elderly. Exercise-
induced skeletal muscle contractions lead to the production and secretion of many small …

The ability to effectively target a tumor to achieve complete regression and cure is the
ultimate goal that drives our need to better understand tumor biology. Recently, SPARC has …

Deregulated expression of SPARC/osteonectin, a secreted glycoprotein with multiple
biological functions, has been associated with the progression of various cancers. Using …

Other than genetic imprinting and epithelial to mesenchymal transition, cancer cells need
interaction with the nearby stroma toward metastasis. Secreted protein acidic and rich in …

Secreted protein acidic and rich in cysteine (SPARC) is an extracellular Ca2+-binding
matricellular glycoprotein that associates with cell populations undergoing migration …

Activation of the matrix metalloproteinase 2 (MMP-2) has been shown to play a major role in
the proteolysis of extracellular matrix (ECM) associated with tumor invasion. Although the …

Although many clinical studies have found a correlation of SPARC expression with
malignant progression and patient survival, the mechanisms for SPARC function in …