Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?
Hosts and bacteria have coevolved over millions of years, during which pathogenic bacteria
have modified their virulence mechanisms to adapt to host defense systems. Although the …
have modified their virulence mechanisms to adapt to host defense systems. Although the …
ESX secretion systems: mycobacterial evolution to counter host immunity
MI Gröschel, F Sayes, R Simeone, L Majlessi… - Nature Reviews …, 2016 - nature.com
Mycobacterium tuberculosis uses sophisticated secretion systems, named 6 kDa early
secretory antigenic target (ESAT6) protein family secretion (ESX) systems (also known as …
secretory antigenic target (ESAT6) protein family secretion (ESX) systems (also known as …
Virulence factors of the Mycobacterium tuberculosis complex
MA Forrellad, LI Klepp, A Gioffré, J Sabio y Garcia… - Virulence, 2013 - Taylor & Francis
The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …
Mycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence
I Smith - Clinical microbiology reviews, 2003 - Am Soc Microbiol
Tuberculosis (TB), one of the oldest known human diseases. is still is one of the major
causes of mortality, since two million people die each year from this malady. TB has many …
causes of mortality, since two million people die each year from this malady. TB has many …
Genome plasticity of BCG and impact on vaccine efficacy
To understand the evolution, attenuation, and variable protective efficacy of bacillus
Calmette–Guérin (BCG) vaccines, Mycobacterium bovis BCG Pasteur 1173P2 has been …
Calmette–Guérin (BCG) vaccines, Mycobacterium bovis BCG Pasteur 1173P2 has been …
Bacterial growth and cell division: a mycobacterial perspective
EC Hett, EJ Rubin - Microbiology and Molecular Biology Reviews, 2008 - Am Soc Microbiol
The genus Mycobacterium is best known for its two major pathogenic species, M.
tuberculosis and M. leprae, the causative agents of two of the world's oldest diseases …
tuberculosis and M. leprae, the causative agents of two of the world's oldest diseases …
Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials
A Arbues, JI Aguilo, J Gonzalo-Asensio, D Marinova… - Vaccine, 2013 - Elsevier
The development of a new tuberculosis vaccine is an urgent need due to the failure of the
current vaccine, BCG, to protect against the respiratory form of the disease. MTBVAC is an …
current vaccine, BCG, to protect against the respiratory form of the disease. MTBVAC is an …
The magic bullets and tuberculosis drug targets
Y Zhang - Annu. Rev. Pharmacol. Toxicol., 2005 - annualreviews.org
▪ Abstract Modern chemotherapy has played a major role in our control of tuberculosis. Yet
tuberculosis still remains a leading infectious disease worldwide, largely owing to …
tuberculosis still remains a leading infectious disease worldwide, largely owing to …
Mycobacterium tuberculosis invasion of macrophages: linking bacterial gene expression to environmental cues
A central feature of Mycobacterium tuberculosis (Mtb) pathogenesis is the ability of Mtb to
survive within macrophages (MØ). Despite its critical importance, our appreciation of the …
survive within macrophages (MØ). Despite its critical importance, our appreciation of the …
The secret lives of the pathogenic mycobacteria
CL Cosma, DR Sherman… - Annual Reviews in …, 2003 - annualreviews.org
▪ Abstract Pathogenic mycobacteria, including the causative agents of tuberculosis and
leprosy, are responsible for considerable morbidity and mortality worldwide. A hallmark of …
leprosy, are responsible for considerable morbidity and mortality worldwide. A hallmark of …