Alpha‐Emitter Radium‐223 Induces STING‐Dependent Pyroptosis to Trigger Robust Antitumor Immunity
M Yang, H Liu, J Lou, J Zhang, C Zuo, M Zhu, X Zhang… - Small, 2024 - Wiley Online Library
Abstract Radium‐223 (223Ra) is the first‐in‐class alpha‐emitter to mediate tumor
eradication, which is commonly thought to kill tumor cells by directly cleaving double‐strand …
eradication, which is commonly thought to kill tumor cells by directly cleaving double‐strand …
Design and in vitro evaluation of 223Ra/99mTc-loaded spherical nano-hydroxyapatite in bone tumor therapy
Y Wang, Y Zhou, D Zhai, H Deng, X Chen - Nanomedicine, 2024 - Taylor & Francis
Aim: Nano-hydroxyapatite (nHA) is a good nanocarrier to load 223Ra, but the low specific
activity (sp. act.) of 223Ra@ nHA limits its application in medicine. Methods: We proposed a …
activity (sp. act.) of 223Ra@ nHA limits its application in medicine. Methods: We proposed a …
Safety and effectiveness of the radium‐223–taxane treatment sequence in patients with metastatic castration‐resistant prostate cancer in a global observational study …
CS Higano, S Dizdarevic, J Logue, T Richardson… - Cancer, 2024 - Wiley Online Library
Background Radium‐223 and taxane chemotherapy each improve survival of patients with
metastatic castration‐resistant prostate cancer (mCRPC). Whether the radium‐223–taxane …
metastatic castration‐resistant prostate cancer (mCRPC). Whether the radium‐223–taxane …
[HTML][HTML] DNA Damage and Repair in PBMCs after Internal Ex Vivo Irradiation with [223Ra]RaCl2 and [177Lu]LuCl3 Mixtures
I Strobel, S Schumann, J Müller, AK Buck… - International Journal of …, 2024 - mdpi.com
The combination of high and low LET radionuclides has been tested in several patient
studies to improve treatment response. Radionuclide mixtures can also be released in …
studies to improve treatment response. Radionuclide mixtures can also be released in …
[PDF][PDF] Alpha-emitter radium-223 mediates STING-dependent pyroptosis to trigger robust tumor immunogenicity
M Yang, C Cheng, J Zhang, C Zuo, M Zhu, X Zhang… - 2022 - scholar.archive.org
Purpose Radium-223 (223Ra) is the rst-in-class alpha-emitter to mediate tumor eradication,
which radiation emitted from alpha-emitter are routinely regarded can reduce tumor burden …
which radiation emitted from alpha-emitter are routinely regarded can reduce tumor burden …