The complement cascade, traditionally considered an effector arm of innate immunity
required for host defense against pathogens, is now recognized as a crucial pathogenic …

Complement is part of the innate immune system. Its major function is recognition and
elimination of pathogens via direct killing and/or stimulation of phagocytosis. Activation of …

Genetically modified immune responses to infections and self-antigens initiate most forms of
GN by generating pathogen-and danger-associated molecular patterns that stimulate Toll …

Anti-C1q autoantibodies are present in sera of patients with several autoimmune diseases,
including systemic lupus erythematosus (SLE). Strikingly, in SLE the presence of anti-C1q is …

In systemic lupus erythematosus, the renal deposition of complement-containing immune
complexes initiates an inflammatory cascade resulting in glomerulonephritis. Activation of …

Tumor necrosis factor alpha (TNFα), a pleiotropic cytokine, plays important inflammatory
roles in renal diseases such as lupus nephritis, anti-neutrophil cytoplasmic antibody (ANCA) …

Membranoproliferative glomerulonephritis (MPGN) type II (dense deposit disease) is an
inflammatory renal disease characterized by electron-dense deposits and complement C3 …

The morphology of healthy podocyte foot processes is necessary for maintaining the
characteristics of the kidney filtration barrier. In most forms of glomerular disease, abnormal …

The prospects for complement-targeted therapy in ANCA-associated vasculitis have been
enhanced by a recent clinical trial in which C5a receptor 1 (C5aR1) inhibition safely …

During the development of nephrotoxic nephritis (NTN) in the mouse, we find that a variety of
chemokines and chemokine receptors are induced: CCR1 (RANTES, MIP-1α), CCR2 (MCP …