[HTML][HTML] A comprehensive overview of RNA deconvolution methods and their application
Tumors are surrounded by a variety of tumor microenvironmental cells. Profiling individual
cells within the tumor tissues is crucial to characterize the tumor microenvironment and its …
cells within the tumor tissues is crucial to characterize the tumor microenvironment and its …
Challenges and opportunities to computationally deconvolve heterogeneous tissue with varying cell sizes using single-cell RNA-sequencing datasets
Deconvolution of cell mixtures in “bulk” transcriptomic samples from homogenate human
tissue is important for understanding disease pathologies. However, several experimental …
tissue is important for understanding disease pathologies. However, several experimental …
Reference-free cell type deconvolution of multi-cellular pixel-resolution spatially resolved transcriptomics data
Recent technological advancements have enabled spatially resolved transcriptomic profiling
but at multi-cellular pixel resolution, thereby hindering the identification of cell-type-specific …
but at multi-cellular pixel resolution, thereby hindering the identification of cell-type-specific …
Transcriptomics for child and adolescent tuberculosis
Tuberculosis (TB) in humans is caused by Mycobacterium tuberculosis (Mtb). It is estimated
that 70 million children (< 15 years) are currently infected with Mtb, with 1.2 million each year …
that 70 million children (< 15 years) are currently infected with Mtb, with 1.2 million each year …
Demystifying emerging bulk RNA-Seq applications: the application and utility of bioinformatic methodology
Significant innovations in next-generation sequencing techniques and bioinformatics tools
have impacted our appreciation and understanding of RNA. Practical RNA sequencing …
have impacted our appreciation and understanding of RNA. Practical RNA sequencing …
Transcriptional networks in at-risk individuals identify signatures of type 1 diabetes progression
LP Xhonneux, O Knight, Å Lernmark… - Science translational …, 2021 - science.org
Type 1 diabetes (T1D) is a disease of insulin deficiency that results from autoimmune
destruction of pancreatic islet β cells. The exact cause of T1D remains unknown, although …
destruction of pancreatic islet β cells. The exact cause of T1D remains unknown, although …
Predictive network analysis identifies JMJD6 and other potential key drivers in Alzheimer's disease
Despite decades of genetic studies on late-onset Alzheimer's disease, the underlying
molecular mechanisms remain unclear. To better comprehend its complex etiology, we use …
molecular mechanisms remain unclear. To better comprehend its complex etiology, we use …
Whole-tissue deconvolution and scRNAseq analysis identify altered endometrial cellular compositions and functionality associated with endometriosis
DG Bunis, W Wang, J Vallvé-Juanico… - Frontiers in …, 2022 - frontiersin.org
The uterine lining (endometrium) exhibits a pro-inflammatory phenotype in women with
endometriosis, resulting in pain, infertility, and poor pregnancy outcomes. The full …
endometriosis, resulting in pain, infertility, and poor pregnancy outcomes. The full …
RNA-seq data science: From raw data to effective interpretation
D Deshpande, K Chhugani, Y Chang… - Frontiers in …, 2023 - frontiersin.org
RNA sequencing (RNA-seq) has become an exemplary technology in modern biology and
clinical science. Its immense popularity is due in large part to the continuous efforts of the …
clinical science. Its immense popularity is due in large part to the continuous efforts of the …
[HTML][HTML] Computational challenges in detection of cancer using cell-free DNA methylation
Cell-free DNA (cfDNA) methylation profiling is considered promising and potentially reliable
for liquid biopsy to study progress of diseases and develop reliable and consistent …
for liquid biopsy to study progress of diseases and develop reliable and consistent …