Context Androgen-deprivation therapy (ADT) is a key component of treatment for aggressive
and advanced prostate cancer, but it has also been associated with adverse effects on bone …

Testosterone is a key hormone in the pathology of metabolic diseases such as obesity. Low
testosterone levels are associated with increased fat mass (particularly central adiposity) …

Objective: To formulate clinical practice guidelines for hormonal replacement in
hypopituitarism in adults. Participants: The participants include an Endocrine Society …

Background: The relative cardiovascular safety of gonadotropin-releasing hormone (GnRH)
antagonists compared with GnRH agonists in men with prostate cancer and known …

Background In advanced prostate cancer (APC), successful drug development as well as
advances in imaging and molecular characterisation have resulted in multiple areas where …

Cancer cachexia is a metabolic syndrome that can be present even in the absence of weight
loss ('precachexia'). Cachexia is often compounded by pre-existing muscle loss, and is …

Background Current approaches to diagnosing testosterone deficiency do not consider the
physiological consequences of various testosterone levels or whether deficiencies of …

Background Sipuleucel-T, an autologous active cellular immunotherapy, has shown
evidence of efficacy in reducing the risk of death among men with metastatic castration …

Prostate cancer is a major cause of cancer morbidity and mortality. Intra-prostatic
inflammation is a risk factor for prostate carcinogenesis, with diet, chemical injury and an …

Metabolic diseases, such as obesity, metabolic syndrome (MetS) and type 2 diabetes (T2D),
are now a widespread pandemic in the developed world. These pathologies show sex …