Mitochondrial biogenesis as a therapeutic target for traumatic and neurodegenerative CNS diseases

EC Simmons, NE Scholpa, RG Schnellmann - Experimental neurology, 2020 - Elsevier
Central nervous system (CNS) diseases, both traumatic and neurodegenerative, are
characterized by impaired mitochondrial bioenergetics and often disturbed mitochondrial …

Mitochondrial-based therapeutics for the treatment of spinal cord injury: mitochondrial biogenesis as a potential pharmacological target

NE Scholpa, RG Schnellmann - Journal of Pharmacology and Experimental …, 2017 - ASPET
Spinal cord injury (SCI) is characterized by an initial trauma followed by a progressive
cascade of damage referred to as secondary injury. A hallmark of secondary injury is …

[HTML][HTML] Promising neuroprotective strategies for traumatic spinal cord injury with a focus on the differential effects among anatomical levels of injury

A Ulndreaj, A Badner, MG Fehlings - F1000Research, 2017 - ncbi.nlm.nih.gov
Traumatic spinal cord injury (SCI) is a devastating condition of motor, sensory, and
autonomic dysfunction. The significant cost associated with the management and lifetime …

Injectable ROS-scavenging hydrogel with MSCs promoted the regeneration of damaged skeletal muscle

H Shan, X Gao, M Zhang, M Huang… - Journal of Tissue …, 2021 - journals.sagepub.com
Skeletal muscle injury is a common disease accompanied by inflammation, and its treatment
still faces many challenges. The local inflammatory microenvironment can be modulated by …

Nanofiber scaffolds as drug delivery systems to bridge spinal cord injury

A Faccendini, B Vigani, S Rossi, G Sandri… - Pharmaceuticals, 2017 - mdpi.com
The complex pathophysiology of spinal cord injury (SCI) may explain the current lack of an
effective therapeutic approach for the regeneration of damaged neuronal cells and the …

Minocycline reduces the severity of autonomic dysreflexia after experimental spinal cord injury

JW Squair, I Ruiz, AA Phillips, MMZ Zheng… - Journal of …, 2018 - liebertpub.com
Spinal cord injury (SCI) is a devastating neurological condition for which there is no effective
treatment to restore neurological function. The development of new treatments for those with …

Improved functional recovery in rat spinal cord injury induced by a drug combination administered with an implantable polymeric delivery system

A Bighinati, ML Focarete, C Gualandi… - Journal of …, 2020 - liebertpub.com
Spinal cord injury (SCI) is an incurable condition, in which a cascade of cellular and
molecular events triggered by inflammation and excitotoxicity impairs endogenous …

Sumatriptan improves the locomotor activity and neuropathic pain by modulating neuroinflammation in rat model of spinal cord injury

K Afshari, A Dehdashtian, NS Haddad… - Neurological …, 2021 - Taylor & Francis
Objectives To investigate the therapeutic effects of sumatriptan in a rat model of spinal cord
injury (SCI) and possible anti-inflammatory and analgesic mechanisms underlying this …

[HTML][HTML] Neuroprotective effects of combined treatment with minocycline and olfactory ensheathing cells transplantation against inflammation and oxidative stress after …

S Pourkhodadad, S Oryan, G Kaka… - Cell Journal …, 2019 - ncbi.nlm.nih.gov
Objective Traumatic spinal cord injury (SCI) is considered one of the most devastating
injuries leading to neuronal disruption. Olfactory ensheathing cells (OECs) and minocycline …

Regional cerebral metabolic levels and turnover in awake rats after acute or chronic spinal cord injury

L Wu, Z Niu, X Hu, H Liu, S Li, L Chen… - The FASEB …, 2020 - repository.uwl.ac.uk
Spinal cord injury (SCI) is a common cause of disability, which often leads to sensorimotor
cortex dysfunction above the spinal injury site. However, the cerebral regional effects on …