There is a growing body of scientific research showing the link between depression and
dementia in Alzheimer's disease (AD). The chronic stress contributes to the formation of …

Alkaloids are a type of natural compound possessing different pharmacological activities.
Natural products, including alkaloids, which originate from plants, have emerged as …

AD is a chronic neurodegenerative disease. Many different signaling pathways, such as
Wnt/β-catenin, Notch, ROS/JNK, and PI3K/Akt/mTOR are involved in Alzheimer's disease …

Alzheimer's disease (AD) is one of the most complex progressive neurological disorders
involving degeneration of neuronal connections in brain cells leading to cell death. AD is …

Alzheimer's disease (AD), as a neurodegenerative disorder, usually develops slowly but
gradually worsens. It accounts for approximately 70% of dementia cases worldwide, and is …

Alzheimer's disease (AD) is the most common neurodegenerative disease among the
elderly. Contemporary treatments can only relieve symptoms but fail to delay disease …

Acetylcholinesterase (AChE) is one of the classical targets in the treatment of Alzheimer's
disease (AD). Inhibition of AChE slows down the hydrolysis of acetycholine and increases …

The acetylcholinesterase (AChE) inhibitors are the main drugs for symptomatic treatment of
neurodegenerative disorders like Alzheimer's disease. A recently designed, synthesized …

In this study, a series of novel benzofuran-based 1, 2, 4-triazole derivatives (10a–e) were
synthesized and evaluated for their inhibitory potential against acetylcholinesterase (AChE) …

The AChE inhibitory activity of alkaloid extracts and compounds has been in the focus of
research on the plants of Amaryllidoideae subfamily since the approval of galanthamine in …