Recent advances on cell culture platforms for in vitro drug screening and cell therapies: from conventional to microfluidic strategies

BD Cardoso, EMS Castanheira… - Advanced …, 2023 - Wiley Online Library
The clinical translations of drugs and nanomedicines depend on coherent pharmaceutical
research based on biologically accurate screening approaches. Since establishing the 2D in …

Perspectives for self-driving labs in synthetic biology

HG Martin, T Radivojevic, J Zucker, K Bouchard… - Current Opinion in …, 2023 - Elsevier
Highlights•Self-driving labs (SDLs) combine automated experiments with AI to direct
them.•Synthetic biology provides a unique opportunity for the development of SDLs.•The …

Biological research and self-driving labs in deep space supported by artificial intelligence

LM Sanders, RT Scott, JH Yang, AA Qutub… - Nature Machine …, 2023 - nature.com
Abstract Space biology research aims to understand fundamental spaceflight effects on
organisms, develop foundational knowledge to support deep space exploration and …

Microfluidics: a concise review of the history, principles, design, applications, and future outlook

MI Hajam, MM Khan - Biomaterials Science, 2024 - pubs.rsc.org
Microfluidic technologies have garnered significant attention due to their ability to rapidly
process samples and precisely manipulate fluids in assays, making them an attractive …

An outlook on the current challenges and opportunities in DNA data storage

MH Raza, S Desai, S Aravamudhan, R Zadegan - Biotechnology Advances, 2023 - Elsevier
Silicon is the gold standard for information storage systems. The exponential generation of
digital information will exhaust the global supply of refined silicon. Therefore, investing in …

Automated in vivo enzyme engineering accelerates biocatalyst optimization

E Orsi, L Schada von Borzyskowski, S Noack… - Nature …, 2024 - nature.com
Achieving cost-competitive bio-based processes requires development of stable and
selective biocatalysts. Their realization through in vitro enzyme characterization and …

Artificial intelligence-enabled multipurpose smart detection in active-matrix electrowetting-on-dielectric digital microfluidics

Z Jia, C Chang, S Hu, J Li, M Ge, W Dong… - Microsystems & …, 2024 - nature.com
An active-matrix electrowetting-on-dielectric (AM-EWOD) system integrates hundreds of
thousands of active electrodes for sample droplet manipulation, which can enable …

Periodic flows in microfluidics

A Mudugamuwa, U Roshan, S Hettiarachchi, H Cha… - Small, 2024 - Wiley Online Library
Microfluidics, the science and technology of manipulating fluids in microscale channels,
offers numerous advantages, such as low energy consumption, compact device size …

Enabling pathway design by multiplex experimentation and machine learning

AG Boob, J Chen, H Zhao - Metabolic Engineering, 2024 - Elsevier
The remarkable metabolic diversity observed in nature has provided a foundation for
sustainable production of a wide array of valuable molecules. However, transferring the …

Recent advances in the use of the CRISPR-Cas system for the detection of infectious pathogens

H Gao, Z Shang, SY Chan, D Ma - Journal of Zhejiang University …, 2022 - Springer
Infectious diseases cause great economic loss and individual and even social anguish.
Existing detection methods lack sensitivity and specificity, have a poor turnaround time, and …