Tumor cells evolve in a complex and heterogeneous environment composed of different cell
types and an extracellular matrix. Current 2D culture methods are very limited in their ability …

Cellular ROS production participates in various cellular functions but its accumulation
decides the cell fate. Malignant cells have higher levels of ROS and active antioxidant …

Lipid metabolic reprogramming is involved in mediating tamoxifen (TAM) response in breast
cancer cells. Published microarray data indicated that ATP citrate lyase (ACLY) is …

The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, also known
as statins, are administered as first-line therapy for hypercholesterolemia, both as primary …

Drug resistance is a serious challenge for platinum anticancer drugs. Platinum complexes
may get over the drug resistance via a distinct mechanism of action. Cholesterol is a key …

Cholesterol is a ubiquitous sterol with many biological functions, which are crucial for proper
cellular signaling and physiology. Indeed, cholesterol is essential in maintaining membrane …

Immunotherapy has emerged as a crucial strategy to combat cancer by “reprogramming” a
patient's own immune system. Although immunotherapy is typically reserved for patients with …

Obesity is known to have important roles in driving prostate cancer aggressiveness and
increased mortality. Multiple mechanisms have been postulated for these clinical …

Metabolic reprogramming is an important cancer hallmark that plays a key role in cancer
malignancies and therapy resistance. Cancer cells reprogram the metabolic pathways to …

Background Sp1 is involved in the recurrence of glioblastoma (GBM) due to the acquirement
of resistance to temozolomide (TMZ). Particularly, the role of Sp1 in metabolic …