Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …

Abstract Aldo-Keto-Reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase
(HSD)/prostaglandin (PG) F 2α synthase) is the only 17β-HSD that is not a short-chain …

Aberrant androgen receptor (AR) activation is the major driver of castrate resistant prostate
cancer (CRPC). CRPC is ultimately fatal and more therapeutic agents are needed to treat …

Glucocorticoid receptor (GR) and androgen receptor (AR) are steroid-inducible transcription
factors (TFs). The GR and the AR are central regulators of various metabolic, homeostatic …

Transcriptional factor EB (TFEB), a master regulator of autophagy and lysosomal
biogenesis, is generally regarded as a pro-survival factor. Here, we identify that besides its …

Androgen receptor (AR) plays an important regulatory role in prostate cancer. AR's
transcriptional activity is regulated by androgenic ligands, but also by post-translational …

Ubiquitination and SUMOylation are two essential components of the ubiquitination
proteasome system playing fundamental roles in protein homeostasis maintenance and …

Cells and soluble mediators of the innate and adaptive immune systems are fundamental
components of the tumor microenvironment. Nuclear factors, eg transcription factors (TFs) …

Simple Summary Altered nuclear receptor signaling is well-established to contribute to a
range of hormone-dependent cancers and therefore they are therapeutic targets, for …

Lung adenocarcinoma (LUADC) belongs to the most prevalent and lethal cancer types. As
15-deoxy-Δ12, 14-prostaglandin J 2 (15d-PGJ 2) displays anti-oxidative,-inflammatory, and …