Deep generative AI models analyzing circulating orphan non-coding RNAs enable detection of early-stage lung cancer

M Karimzadeh, A Momen-Roknabadi… - Nature …, 2024 - nature.com
Liquid biopsies have the potential to revolutionize cancer care through non-invasive early
detection of tumors. Developing a robust liquid biopsy test requires collecting high …

A deep learning model predicts the presence of diverse cancer types using circulating tumor cells

S Albaradei, N Alganmi, A Albaradie, E Alharbi… - Scientific reports, 2023 - nature.com
Circulating tumor cells (CTCs) are cancer cells that detach from the primary tumor and
intravasate into the bloodstream. Thus, non-invasive liquid biopsies are being used to …

Scopolin obtained from Smilax china L. against hepatocellular carcinoma by inhibiting glycolysis: A network pharmacology and experimental study

C Wang, Q Zhou, ST Wu - Journal of Ethnopharmacology, 2022 - Elsevier
Ethnopharmacological relevance Smilax china L. is a well-known traditional medicinal plant.
In China, it is a common anti-cancer drug that has been inherited for thousands of years …

Network pharmacology and bioinformatics analysis identifies potential therapeutic targets of Naringenin against COVID-19/LUSC

W Wu, X Jiao, W Song, P Wu, P Xiao… - Frontiers in …, 2023 - frontiersin.org
Background Coronavirus disease 2019 (COVID‐19) is a highly contagious respiratory
disease that has posed a serious threat to people's daily lives and caused an …

Integrated network pharmacology, molecular docking, molecular simulation, and in vitro validation revealed the bioactive components in soy-fermented food products …

AEO Elkhalifa, H Banu, MI Khan, SA Ashraf - Nutrients, 2023 - mdpi.com
Globally, lung cancer remains one of the leading causes of cancer-related mortality,
warranting the exploration of novel and effective therapeutic approaches. Soy-fermented …

Construction of a novel cuproptosis-related gene signature for predicting prognosis and estimating tumor immune microenvironment status in papillary thyroid …

L Wang, B Yao, J Yang, Z Tian, J He - BMC cancer, 2022 - Springer
Background Cuproptosis, a new form of programmed cell death, has been recently reported
to be closely related to tumor progression. However, the significance of cuproptosis-related …

Network medicine in ovarian cancer: topological properties to drug discovery

K Chirom, MZ Malik, IR Mangangcha… - Briefings in …, 2022 - academic.oup.com
Network medicine provides network theoretical tools, methods and properties to study
underlying laws governing human interactome to identify disease states and disease …

Toxicity induced by orellanine from the mushroom Cortinarius orellanus in primary renal tubular proximal epithelial cells (RPTEC): Novel mechanisms of action

SD Nusair, B Abandah, QY Al-Share, L Abu-Qatouseh… - Toxicon, 2023 - Elsevier
The toxicity of Orellanine (OR), a significant factor in mushroom poisoning, has severe
effects on the kidneys, particularly the proximal tubules. This study investigated the acute …

Identification of microRNA and gene interactions through bioinformatic integrative analysis for revealing candidate signatures in prostate cancer

MM Khan, M Serajuddin, MZ Malik - Gene Reports, 2022 - Elsevier
Abstract Background Prostate cancer (PCa) is a most common diagnosed cancer among
males globally. Despite the decreased PCa mortality, increased prevalence of it creates …

A bioinformatics approach to elucidate conserved genes and pathways in C. elegans as an animal model for cardiovascular research

AK Ray, A Priya, MZ Malik, TA Thanaraj, AK Singh… - Scientific Reports, 2024 - nature.com
Cardiovascular disease (CVD) is a collective term for disorders of the heart and blood
vessels. The molecular events and biochemical pathways associated with CVD are difficult …