Scorpion venom: detriments and benefits

S Ahmadi, JM Knerr, L Argemi, KCF Bordon, MB Pucca… - Biomedicines, 2020 - mdpi.com
Scorpion venom may cause severe medical complications and untimely death if injected into
the human body. Neurotoxins are the main components of scorpion venom that are known to …

Lipid metabolism in inflammation-related diseases

C Zhang, K Wang, L Yang, R Liu, Y Chu, X Qin, P Yang… - Analyst, 2018 - pubs.rsc.org
There are thousands of lipid species existing in cells, which belong to eight different
categories. Lipids are the essential building blocks of cells. Recent studies have started to …

[HTML][HTML] Arachidonic acid inhibition of the NLRP3 inflammasome is a mechanism to explain the anti-inflammatory effects of fasting

M Pereira, J Liang, J Edwards-Hicks, AM Meadows… - Cell reports, 2024 - cell.com
Summary Elevated interleukin (IL)-1β levels, NLRP3 inflammasome activity, and systemic
inflammation are hallmarks of chronic metabolic inflammatory syndromes, but the …

Scorpion envenomation in Brazil: Current scenario and perspectives for containing an increasing health problem

C Guerra-Duarte, R Saavedra-Langer… - PLoS neglected …, 2023 - journals.plos.org
Opportunistic scorpion species can colonize urban environments, establishing high-density
communities that enhance the chances of human accidents. This scenario has been taking …

Prostaglandin E2 as a regulator of immunity to pathogens

GJ Martínez-Colón, BB Moore - Pharmacology & therapeutics, 2018 - Elsevier
The body is exposed to foreign pathogens every day, but remarkably, most pathogens are
effectively cleared by the innate immune system without the need to invoke the adaptive …

Nonsteroidal anti‐inflammatory therapy: a journey toward safety

C Pereira‐Leite, C Nunes, SK Jamal… - Medicinal research …, 2017 - Wiley Online Library
The efficacy of nonsteroidal anti‐inflammatory drugs (NSAIDs) against inflammation, pain,
and fever has been supporting their worldwide use in the treatment of painful conditions and …

GPSM1 impairs metabolic homeostasis by controlling a pro-inflammatory pathway in macrophages

J Yan, Y Zhang, H Yu, Y Zong, D Wang, J Zheng… - Nature …, 2022 - nature.com
Abstract G-protein-signaling modulator 1 (GPSM1) exhibits strong genetic association with
Type 2 diabetes (T2D) and Body Mass Index in population studies. However, how GPSM1 …

Inflammasomes: Pandora's box for sepsis

V Kumar - Journal of inflammation research, 2018 - Taylor & Francis
Sepsis was known to ancient Greeks since the time of great physician Hippocrates (460–
377 BC) without exact information regarding its pathogenesis. With time and medical …

Extracellular histones activate endothelial NLRP3 inflammasome and are associated with a severe sepsis phenotype

J Beltrán-García, R Osca-Verdegal… - Journal of …, 2022 - Taylor & Francis
Introduction Circulating extracellular histones acquire relevance as cytotoxic mediators in
sepsis. Extracellular histones act as damage-associated molecular patterns (DAMPs), which …

Immune-regulation and-functions of eicosanoid lipid mediators

J Esser-von Bieren - Biological chemistry, 2017 - degruyter.com
Bioactive lipids regulate most physiological processes, from digestion to blood flow and from
hemostasis to labor. Lipid mediators are also involved in multiple pathologies including …