Organosulfur compounds have long played a vital role in organic chemistry and in the
development of novel chemical structures and architectures. Prominent among these …

This Perspective illustrates the defining characteristics of free radical chemistry, beginning
with its rich and storied history. Studies from our laboratory are discussed along with recent …

Fluorine has emerged as a “magic element” in medicinal chemistry, crop, and materials
science. 1 Although fluorine is the most abundant halogen in the earth's crust, it is contained …

Fluorine, often called as “a small atom with a big ego”, 1 lies in the second row and the 17th
column in the periodic table of the chemical elements. This unique position in the periodic …

The incorporation of a trifluoromethyl (CF3) group into organic compounds is of great
importance in pharmaceutical, agricultural, and materials science. Trifluoromethylation …

C–H functionalization chemistry is one of the most vibrant research areas within synthetic
organic chemistry. While most researchers focus on the development of small-scale batch …

Abstract Sodium trifluoromethanesulfinate, CF 3 SO 2 Na, and trifluoromethanesulfonyl
chloride, CF 3 SO 2 Cl, are two popular reagents that are widely used for the direct …

The fluoride [(bpy) CuF2 (H2O)]· 2H2O (1) reacts with CF3SiMe3 and PhB (OH) 2 in DMF at
rt to give PhCF3 in> 95% yield within 15 min. Although 1 is a Cu (II) complex, this reaction …

Metal-assisted trifluoromethylation and perfluoroalkylation reactions are probably one of the
first approaches employed to achieve fluoroalkyl-group substitutions of organic substrates …

A copper-catalysed ring-opening trifluoromethylation reaction of cyclopropanols has been
developed. Various β-trifluoromethyl ketones are obtained in good to excellent yields under …