An increase in dementia numbers and global trends in population aging across the world
prompts the need for new medications to treat the complex biological dysfunctions, such as …

Alzheimer's disease (AD) is a genetically complex, progressive and irreversible
neurodegenerative disorder of the brain which involves multiple associated etiological …

The complications of Alzheimer's disease AD were deadly dangerous cause of
neurodegenerative disorders connected with the decline of the cognitive functions and loss …

A series of novel tacrine derivatives and tacrine–coumarin heterodimers were designed,
synthesized, and biologically evaluated for their potential inhibitory effect on both …

Acetylcholinesterase is an important biochemical enzyme in that it controls acetylcholine-
mediated neuronal transmission in the central nervous system, contains a unique structure …

Alzheimer´ s disease (AD) is a progressive neurodegenerative dementia which currently
represents one of the biggest threats for the human kind. The cure is still unknown and …

A series of previously synthesized conjugates of tacrine and salicylamide was extended by
varying the structure of the salicylamide fragment and using salicylic aldehyde to synthesize …

Alzheimer's disease is a neurological disorder, which is the most common form of dementia
affecting mostly elderly people. The number of patients is still rapidly increasing which …

We report herein the design and synthesis of a series of 11 novel tacrine-1, 2, 3-triazole
derivatives via a Cu (I)-catalyzed alkyne–azide 1, 3-dipolar cycloaddition (CuAAC) reaction …

Alzheimer's disease (AD) is a complex neurodegenerative disease that leads to insidious
deterioration of brain functions and is considered the sixth leading cause of death in the …