Extracellular matrix structure

AD Theocharis, SS Skandalis, C Gialeli… - Advanced drug delivery …, 2016 - Elsevier
Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network
composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins …

The instructive extracellular matrix of the lung: basic composition and alterations in chronic lung disease

G Burgstaller, B Oehrle, M Gerckens… - European …, 2017 - Eur Respiratory Soc
The pulmonary extracellular matrix (ECM) determines the tissue architecture of the lung, and
provides mechanical stability and elastic recoil, which are essential for physiological lung …

Extracellular matrix assembly: a multiscale deconstruction

JK Mouw, G Ou, VM Weaver - Nature reviews Molecular cell biology, 2014 - nature.com
The biochemical and biophysical properties of the extracellular matrix (ECM) dictate tissue-
specific cell behaviour. The molecules that are associated with the ECM of each tissue …

[HTML][HTML] Into the tissues: Extracellular matrix and its artificial substitutes: Cell signalling mechanisms

A Bandzerewicz, A Gadomska-Gajadhur - Cells, 2022 - mdpi.com
The existence of orderly structures, such as tissues and organs is made possible by cell
adhesion, ie, the process by which cells attach to neighbouring cells and a supporting …

[HTML][HTML] Extracellular matrix composition of connective tissues: a systematic review and meta-analysis

TJ McKee, G Perlman, M Morris, SV Komarova - Scientific reports, 2019 - nature.com
The function of connective tissues depends on the physical and biochemical properties of
their extracellular matrix (ECM), which are in turn dictated by ECM protein composition. With …

Elastin, arterial mechanics, and cardiovascular disease

AJ Cocciolone, JZ Hawes… - American Journal …, 2018 - journals.physiology.org
Large, elastic arteries are composed of cells and a specialized extracellular matrix that
provides reversible elasticity and strength. Elastin is the matrix protein responsible for this …

[HTML][HTML] Extracellular matrix dynamics: tracking in biological systems and their implications

M Hu, Z Ling, X Ren - Journal of Biological Engineering, 2022 - Springer
The extracellular matrix (ECM) constitutes the main acellular microenvironment of cells in
almost all tissues and organs. The ECM not only provides mechanical support, but also …

The myofibroblast matrix: implications for tissue repair and fibrosis

F Klingberg, B Hinz, ES White - The Journal of pathology, 2013 - Wiley Online Library
Myofibroblasts, and the extracellular matrix (ECM) in which they reside, are critical
components of wound healing and fibrosis. The ECM, traditionally viewed as the structural …

[HTML][HTML] Matrix metalloproteinase interactions with collagen and elastin

SR Van Doren - Matrix Biology, 2015 - Elsevier
Most abundant in the extracellular matrix are collagens, joined by elastin that confers elastic
recoil to the lung, aorta, and skin. These fibrils are highly resistant to proteolysis but can …

[HTML][HTML] In situ heart valve tissue engineering using a bioresorbable elastomeric implant–From material design to 12 months follow-up in sheep

J Kluin, H Talacua, AIPM Smits, MY Emmert… - Biomaterials, 2017 - Elsevier
The creation of a living heart valve is a much-wanted alternative for current valve prostheses
that suffer from limited durability and thromboembolic complications. Current strategies to …