The model of asthma as a single entity has now been replaced by a much more complex
biological network of distinct and interrelating inflammatory pathways. The term asthma is …

Asthma is a chronic inflammatory airway disease associated with type 2 cytokines
interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus …

Mast cells are hematopoietic cells that reside in virtually all vascularized tissues and that
represent potential sources of a wide variety of biologically active secreted products …

CD4+ T helper (TH) cells and regulatory T (Treg) cells that respond to common allergens
play an important role in driving and dampening airway inflammation in patients with …

Monoclonal antibodies targeting IgE or the type-2 cytokines interleukin (IL)-4, IL-5 and IL-13
are proving highly effective in reducing exacerbations and symptoms in people with severe …

Although the term “asthma” has been applied to all patients with airway lability and variable
chest symptoms for centuries, phenotypes of asthma with distinct clinical and molecular …

Background More than 300 million people carry a diagnosis of asthma, with data to suggest
that they are at a higher risk for infection or adverse outcomes from severe acute respiratory …

Background Type 1 (T1) inflammation (marked by IFN-γ expression) is now consistently
identified in subsets of asthma cohorts, but how it contributes to disease remains unclear …

There is unprecedented opportunity to use machine learning to integrate high-dimensional
molecular data with clinical characteristics to accurately diagnose and manage disease …

While the term asthma has long been known to describe heterogeneous groupings of
patients, only recently have data evolved which enable a molecular understanding of the …