Pharmacological strategies for pain management have primarily focused on dampening
ascending neurotransmission and on opioid receptor–mediated therapies. Little is known …

Placebo and nocebo effects are embodied psycho-neurobiological responses capable of
modulating pain and producing changes at different neurobiological, body at perceptual and …

The primary objective of this paper is to discuss how a resilience approach to (chronic) pain
may advance our current understanding of (mal) adaptation to pain. Different resilience …

Accumulating evidence reveal important applications of endogenous pain modulation
assessment in healthy controls and in patients in clinical settings, as dysregulations in the …

Chronic pain in children and adolescents is a common and debilitating health problem. This
narrative review will give a brief overview on what pediatric chronic pain is and what …

Caregiver report is the most common measure of change in pediatric psychiatry. Yet,
placebo response rates pose significant challenges to reliably detect a treatment response …

The “placebo (effect) by proxy”(PbP) concept, introduced by Grelotti and Kaptchuk (1),
describes a positive effect of a patient's treatment on persons in their surrounding such as …

Objective Reliably identifying good placebo responders has pronounced implications for
basic research on, and clinical applications of, the placebo response. Multiple studies point …

Variability in pain-related outcomes can hamper assay sensitivity of chronic pain clinical
trials. Expectations of outcome in such trials may account for some of this variability, and …

Expectations and beliefs shape the experience of pain. This is most evident in context-
induced, placebo analgesia, which has recently been shown to interact with the trait of …