Angiogenesis is the formation of new capillaries from pre-existing vasculature, which plays a
critical role in the pathogenesis of several inflammatory autoimmune diseases such as …

The vast blood-vessel network of the circulatory system is crucial for maintaining bodily
homeostasis, delivering essential molecules and blood cells, and removing waste products …

Angiogenesis is crucial for the success of most tissue engineering strategies. The natural
inflammatory response is a major regulator of vascularization, through the activity of different …

T-regulatory cells (Tregs) are found infiltrating tumors in a vast array of tumor types, and
tumor-infiltrating Tregs are often associated with a poor clinical outcome. Tregs are potent …

The'seed and soil'hypothesis for metastasis sets forth the concept that a conducive
microenvironment, or niche, is required for disseminating tumour cells to engraft distant …

Emerging evidence indicates that angiogenesis and immunosuppression frequently occur
simultaneously in response to diverse stimuli. Here, we describe a fundamental biological …

One of the fundamental traits of immune cells in rheumatoid arthritis (RA) is their ability to
proliferate, a property shared with the joint-resident cells that form the synovial pannus. The …

The normal intervertebral disc (IVD) is a poorly innervated organ supplied only by sensory
(mainly nociceptive) and postganglionic sympathetic (vasomotor efferents) nerve fibers …

The endothelium is crucially important for the delivery of oxygen and nutrients throughout
the body under homeostatic conditions. However, it also contributes to pathology, including …

Angiogenesis is an early and a critical event in the pathogenesis of rheumatoid arthritis
(RA). Neovascularization is dependent on endothelial cell activation, migration and …