Tumor Treating Fields dually activate STING and AIM2 inflammasomes to induce adjuvant immunity in glioblastoma

D Chen, SB Le, TE Hutchinson… - The Journal of …, 2022 - Am Soc Clin Investig
Tumor Treating Fields (TTFields), an approved therapy for glioblastoma (GBM) and
malignant mesothelioma, employ noninvasive application of low-intensity, intermediate …

The evolving role of tumor treating fields in managing glioblastoma: guide for oncologists

SH Burri, V Gondi, PD Brown… - American journal of …, 2018 - journals.lww.com
Glioblastoma (GBM) is a devastating brain tumor with poor prognosis despite advances in
surgery, radiation, and chemotherapy. Survival of patients with glioblastoma remains poor …

[HTML][HTML] Post hoc analyses of intention-to-treat population in phase III comparison of NovoTTF-100A™ system versus best physician's choice chemotherapy

AA Kanner, ET Wong, JL Villano, Z Ram… - Seminars in …, 2014 - Elsevier
We performed a treatment-based analysis of data from the pivotal phase III trial of the
NovoTTF-100A System™ versus best physician's choice (BPC) chemotherapy in patients …

Understanding and therapeutically exploiting cGAS/STING signaling in glioblastoma

JT Low, MC Brown, ZJ Reitman… - The Journal of …, 2024 - Am Soc Clin Investig
Since the discovery that cGAS/STING recognizes endogenous DNA released from dying
cancer cells and induces type I interferon and antitumor T cell responses, efforts to …

[HTML][HTML] Response patterns of recurrent glioblastomas treated with tumor-treating fields

J Vymazal, ET Wong - Seminars in oncology, 2014 - Elsevier
Glioblastoma multiforme (GBM) is the most common form of primary malignant brain cancer.
Median overall survival (OS) for newly diagnosed patients is only about 12 to 18 months …

The effects of alternating electric fields in glioblastoma: current evidence on therapeutic mechanisms and clinical outcomes

AA Rehman, KB Elmore, TA Mattei - Neurosurgical focus, 2015 - thejns.org
Glioblastoma is both the most common and most lethal primary CNS malignancy in adults,
accounting for 45.6% of all malignant CNS tumors, with a 5-year survival rate of only 5.0 …

Estimated lifetime survival benefit of tumor treating fields and temozolomide for newly diagnosed glioblastoma patients

GF Guzauskas, M Salzberg, BCM Wang - CNS oncology, 2018 - Taylor & Francis
Aim: To estimate the mean lifetime survival benefit, an essential component of health
economic evaluations in oncology, of adding tumor treating fields (TTFields) to maintenance …

Proliferation arrest, selectivity, and chemosensitivity enhancement of cancer cells treated by a low-intensity alternating electric field

KF Lei, SC Hsieh, A Goh, RL Kuo, NM Tsang - Biomedical Microdevices, 2018 - Springer
Elimination of serious side effects is a desired feature of cancer therapy. Alternating electric
field treatment is one approach to the non-invasive treatment of cancer. The efficacy and …

Amino acid PET imaging of the early metabolic response during tumor-treating fields (TTFields) therapy in recurrent glioblastoma

E Bosnyák, GR Barger, SK Michelhaugh… - Clinical nuclear …, 2018 - journals.lww.com
Tumor-treating fields (TTFields) therapy is a relatively new treatment approach for malignant
gliomas. We evaluated if amino acid PET can detect an objective metabolic response to …

Investigation of uniform sized multicellular spheroids raised by microwell arrays after the combined treatment of electric field and anti-cancer drug

KF Lei, WW Ji, A Goh, CH Huang, MY Lee - Biomedical Microdevices, 2019 - Springer
Nowadays, cancer disease is continuously identified as the leading cause of mortality
worldwide. Cancer chemotherapeutic agents have been continuously developing to achieve …