The intention behind the design of a metal complex is quite crucial for its development
towards a particular application. Transition metal complexes have tremendously become …

Poor responses to medical care and the failure of pharmacological treatment for many high-
frequency diseases, such as cancer and viral infections, have been widely documented. In …

The biological efficacy of half-sandwich platinum group organometallic complexes of the
formula [(η5-Cpx)/(η6-arene) M (XY) Cl] 0/+(XY= bidentate ligands; Cpx= functionalized …

Nanomaterials with peroxidase-like activity and photothermal conversion efficiency have
garnered significant attention for their ability to generate cytotoxic hydroxyl radicals and …

The evolution of chemotherapy, especially the dawn of metal‐based drugs, represents a
transformative era in cancer treatment. From the serendipitous discovery of mustard gas's …

Chemoresistance remains an arduous challenge in oncology, but ferroptosis shows
potential for overcoming it by stimulating the immune system. Herein, a novel high …

The incorporation of an organelle-targeting moiety into compounds has proven to be an
effective strategy in the development of targeted anticancer drugs. We herein report the …

Six half-sandwich Ru (II) complexes (Ru1-Ru6), integrated with 5-phenyl-2-(pyridin-2-yl)-2, 4-
dihydro-3H-pyrazol-3-one (PDPO1-PDPO6) ligands, were synthesized and …

The relentless increase in drug resistance of platinum-based chemotherapeutics has
opened the scope for other new cancer therapies with novel mechanisms of action (MoA) …

This study presents the development and evaluation of triphenylphosphine-modified
cyclometalated iridium III complexes as selective anticancer agents targeting mitochondria …