Traditionally, invasive coronary physiological assessment has focused on the epicardial
coronary artery. More recently, appreciation of the importance of the coronary …

Regulated vascular permeability is an essential feature of normal physiology and its
dysfunction is associated with major human diseases ranging from cancer to inflammation …

Cochrane, Maria Crespo Leiro, Anne Dipchand, Brian Feingold, Kathleen Grady, Edward
Horn, Maryl Johnson, Donna Mancini, Sean Pinney, Heather Ross, Kari Wujcik, Andreas …

Background: After heart transplantation, endomyocardial biopsy (EMBx) is used to monitor
for acute rejection (AR). Unfortunately, EMBx is invasive, and its conventional histological …

Cardiac allograft vasculopathy remains a major limiting factor in the long-term survival of the
heart transplant recipient. Our understanding of its pathogenesis is continuously evolving as …

Aims We evaluated the long-term prognostic value of invasively assessing coronary
physiology after heart transplantation in a large multicentre registry. Methods and results …

Background: Early cardiac allograft vasculopathy (CAV) prognostication is needed to
improve long-term outcomes after heart transplantation. We characterized first year …

Cardiovascular diseases (CVDs), the leading cause of death worldwide, share in common
mitochondrial dysfunction, in specific a dysregulation of Ca2+ uptake dynamics through the …

Abstract Purpose of Review Cardiac allograft vasculopathy (CAV) is a late-occurring
complication of heart transplantation significantly limiting overall graft survival. In the last few …

Background Single-center data suggest that the index of microcirculatory resistance (IMR)
measured early after heart transplantation predicts subsequent acute rejection. Objectives …