Controlled drug delivery vehicles for cancer treatment and their performance

S Senapati, AK Mahanta, S Kumar… - Signal transduction and …, 2018 - nature.com
Although conventional chemotherapy has been successful to some extent, the main
drawbacks of chemotherapy are its poor bioavailability, high-dose requirements, adverse …

PCL-PEG copolymer based injectable thermosensitive hydrogels

MR Dethe, A Prabakaran, H Ahmed, M Agrawal… - Journal of Controlled …, 2022 - Elsevier
A number of stimuli-responsive-based hydrogels has been widely explored in biomedical
applications in the last few decades because of their excellent biodegradability and …

Injectable hydrogel-based drug delivery systems for local cancer therapy

M Norouzi, B Nazari, DW Miller - Drug discovery today, 2016 - Elsevier
Highlights•Hydrogel-based drug delivery systems can be more efficacious than the systemic
therapies.•They provide a high concentration and a sustained release of the drugs at tumor …

Structured macroporous hydrogels: Progress, challenges, and opportunities

KJ De France, F Xu, T Hoare - Advanced healthcare materials, 2018 - Wiley Online Library
Structured macroporous hydrogels that have controllable porosities on both the nanoscale
and the microscale offer both the swelling and interfacial properties of bulk hydrogels as well …

Glutathione responsive polymers and their application in drug delivery systems

JF Quinn, MR Whittaker, TP Davis - Polymer Chemistry, 2017 - pubs.rsc.org
Materials which respond to biological cues are the subject of intense research interest due
to their possible application in smart drug delivery vehicles. In particular, novel polymers …

Hydrogels that listen to cells: a review of cell-responsive strategies in biomaterial design for tissue regeneration

HW Ooi, S Hafeez, CA Van Blitterswijk, L Moroni… - Materials …, 2017 - pubs.rsc.org
The past decade has seen a decided move from static and passive biomaterials to
biodegradable, dynamic, and stimuli responsive materials in the laboratory and the clinic …

Functional microgels: recent advances in their biomedical applications

G Agrawal, R Agrawal - Small, 2018 - Wiley Online Library
Here, a spotlight is shown on aqueous microgel particles which exhibit a great potential for
various biomedical applications such as drug delivery, cell imaging, and tissue engineering …

Chemical stimuli-induced reversible bond cleavage in covalently crosslinked hydrogels

S Shahi, H Roghani-Mamaqani, S Talebi… - Coordination Chemistry …, 2022 - Elsevier
Stimuli-responsive hydrogels are known as a new category of smart materials with
responsivity toward various stimulants. Controllable reversible bond dissociation and …

Design of polymeric gene carriers for effective intracellular delivery

WF Lai, WT Wong - Trends in biotechnology, 2018 - cell.com
Polymeric carriers have emerged as major non-viral alternatives for gene delivery due to
their lower immunogenicity and pathogenicity. However, during intracellular delivery of …

Temperature-sensitive polymersomes for controlled delivery of anticancer drugs

F Liu, V Kozlovskaya, S Medipelli, B Xue… - Chemistry of …, 2015 - ACS Publications
We report on a novel type of triblock copolymer polymersomes with temperature-controlled
permeability within the physiologically relevant temperature range of 37–42° C for sustained …