The skin is the largest organ of the body, having a complex multi-layered structure and
guards the underlying muscles, bones, ligaments, and internal organs. It serves as the first …

The functional significance of multiple cells--among lymphoid and nonlymphoid cells--
capable of having Ia molecules on their membranes must be critically addressed. Ia is …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

Murine epidermal Langerhans cells (LC) have been studied in tissue culture and compared
to spleen dendritic cells (DC). LC comprised 3% of the starting cell suspensions and were …

Langerhans cells (LCs) are antigen‐presenting dendritic cells (DCs) that reside in epithelia.
The best studied example is the LC of the epidermis. By electron microscopy, their …

LANGERHANS cells (LC) are the principal accessory cells present in epidermis1. Because
LC have limited capacity for self-renewal2, epidermis is continually repopulated by as-yet …

Langerhans cells constitute a morphologically well characterised subpopulation (3–8%) of
mammalian epidermal cells which, in contrast to the bulk of epidermal cells, bear Fc-IgG and …

X-chromosome-inactiavtion assays can be used to assess clonality. We used such an assay
at the human androgen-receptor gene locus in three female patients with histologically …

Langerhans cells (LCs) constitute a subset of DCs that initiate immune responses in skin.
Using leprosy as a model, we investigated whether expression of CD1a and langerin, an LC …

In this study, we have used a mouse monoclonal antibody to rat Ia (RT1-B or class II)
antigens to demonstrate, by immunofluorescence on frozen sections, intensely Ia-positive …