Modern advances in heterocyclic chemistry in drug discovery
AP Taylor, RP Robinson, YM Fobian… - Organic & …, 2016 - pubs.rsc.org
New advances in synthetic methodologies that allow rapid access to a wide variety of
functionalized heterocyclic compounds are of critical importance to the medicinal chemist as …
functionalized heterocyclic compounds are of critical importance to the medicinal chemist as …
Development of Novel 1,3-Disubstituted-2-Thiohydantoin Analogues with Potent Anti-Inflammatory Activity; In Vitro and In Silico Assessments
Inflammation is the main cause of several autoimmune diseases, including type I diabetes,
rheumatoid arthritis, bullous pemphigoid, paraneoplastic pemphigoid, and multiple …
rheumatoid arthritis, bullous pemphigoid, paraneoplastic pemphigoid, and multiple …
Synthesis of multiply arylated heteroarenes, including bioactive derivatives, via palladium-catalyzed direct C–H arylation of heteroarenes with (pseudo) aryl halides or …
This review with 387 references covers the literature until the end of November 2013 on the
synthesis of multiply arylated heteroarenes via highly selective palladium-catalyzed direct C …
synthesis of multiply arylated heteroarenes via highly selective palladium-catalyzed direct C …
Direct (hetero) arylation reactions of (hetero) arenes as tools for the step-and atom-economical synthesis of biologically active unnatural compounds including …
The significant number of papers and reviews published in this last decade testifies to the
utility of the transition-metal-catalyzed direct C–H (hetero) arylation reactions of (hetero) …
utility of the transition-metal-catalyzed direct C–H (hetero) arylation reactions of (hetero) …
A novel three-step synthesis of Celecoxib via palladium-catalyzed direct arylation
SM Gaulier, R McKay, NA Swain - Tetrahedron letters, 2011 - Elsevier
A novel three-step synthesis of Celecoxib via palladium-catalyzed direct arylation - ScienceDirect
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[HTML][HTML] Efficacy of intra-articular injection of celecoxib in a rabbit model of osteoarthritis
D Jiang, J Zou, L Huang, Q Shi, X Zhu, G Wang… - International journal of …, 2010 - mdpi.com
Introduction: Osteoarthritis is the most common form of arthritis. It is a slowly progressive joint
disease typically seen in middle-age to elderly people. Intra-articular injection of hyaluronic …
disease typically seen in middle-age to elderly people. Intra-articular injection of hyaluronic …
[HTML][HTML] GW0742 as a Potential TRα and TRβ Antagonist Reduces the Viability and Metabolic Activity of an Adult Granulosa Tumour Cell Line and Simultaneously …
J Gogola-Mruk, I Kumor, G Wojtaszek, K Kulig, A Ptak - Cancers, 2024 - mdpi.com
Abstract Background/Objectives: Clinical studies have demonstrated a correlation between
alterations in the expression level of TRα and TRβ receptors in ovarian cancer cells and …
alterations in the expression level of TRα and TRβ receptors in ovarian cancer cells and …
An efficient regioselective copper catalyzed multi-component synthesis of 1, 3-disubstituted pyrazoles
A Raghunadh, SB Meruva, R Mekala, KR Rao… - Tetrahedron …, 2014 - Elsevier
An efficient synthesis of unsymmetrically substituted 1, 3-pyrazole derivatives has been
developed via three-component coupling reaction involving 3-(dimethylamino)-1 …
developed via three-component coupling reaction involving 3-(dimethylamino)-1 …
Aryl/heteroaryl substituted celecoxib derivatives as COX-2 inhibitors: Synthesis, anti-inflammatory activity and molecular docking studies
G Madhava, KV Ramana, SM Sudhana… - Medicinal …, 2017 - ingentaconnect.com
Background: Cyclooxygenase (COX-2) inhibitors have been developed to provide better anti-
inflammatory and analgesic efficacy than those of traditional NSAIDs. Several compounds …
inflammatory and analgesic efficacy than those of traditional NSAIDs. Several compounds …
[HTML][HTML] Ionic liquid-assisted synthesis of celexocib using tris-(2-hydroxyethyl) ammonium acetate as an efficient and reusable catalyst
HR Ahfad-Hosseini, H Bagheri… - Iranian Journal of …, 2017 - ncbi.nlm.nih.gov
Celecoxib is classified as none traditional nonsteroidal anti-inflammatory drugs (NSAIDs).
This compound has conventional properties of NSAIDs such as anti-inflammatory …
This compound has conventional properties of NSAIDs such as anti-inflammatory …