Obstructive sleep apnea, hypoxia, and nonalcoholic fatty liver disease

OA Mesarwi, R Loomba, A Malhotra - American journal of …, 2019 - atsjournals.org
Recent studies have demonstrated that obstructive sleep apnea (OSA) is associated with the
development and evolution of nonalcoholic fatty liver disease (NAFLD), independent of …

The impact of sleep disorders on glucose metabolism: endocrine and molecular mechanisms

A Briançon-Marjollet, M Weiszenstein, M Henri… - Diabetology & metabolic …, 2015 - Springer
Modern lifestyle has profoundly modified human sleep habits. Sleep duration has shortened
over recent decades from 8 to 6.5 hours resulting in chronic sleep deprivation. Additionally …

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

Y Kojima, JP Volkmer, K McKenna, M Civelek, AJ Lusis… - Nature, 2016 - nature.com
Atherosclerosis is the disease process that underlies heart attack and stroke. Advanced
lesions at risk of rupture are characterized by the pathological accumulation of diseased …

Obstructive sleep apnea and risk of cardiovascular events and all-cause mortality: a decade-long historical cohort study

T Kendzerska, AS Gershon, G Hawker, RS Leung… - PLoS …, 2014 - journals.plos.org
Background Obstructive sleep apnea (OSA) has been reported to be a risk factor for
cardiovascular (CV) disease. Although the apnea-hypopnea index (AHI) is the most …

Obstructive sleep apnea syndrome

MR Mannarino, F Di Filippo, M Pirro - European journal of internal medicine, 2012 - Elsevier
Obstructive sleep apnea (OSA) syndrome is a common but often unrecognized disorder
caused by pharyngeal collapse during sleep and characterized by frequent awakenings …

Obstructive sleep apnea: an emerging risk factor for atherosclerosis

LF Drager, VY Polotsky, G Lorenzi-Filho - Chest, 2011 - Elsevier
Obstructive sleep apnea (OSA) is independently associated with death from cardiovascular
diseases, including myocardial infarction and stroke. Myocardial infarction and stroke are …

Inflammation in sleep apnea: an update

D Unnikrishnan, J Jun, V Polotsky - Reviews in Endocrine and Metabolic …, 2015 - Springer
Obstructive sleep apnea (OSA) is a common disorder associated with cardiovascular
disease (CVD). One theory to explain this relationship proposes that OSA can induce …

Adipose tissue inflammation by intermittent hypoxia: mechanistic link between obstructive sleep apnoea and metabolic dysfunction

S Ryan - The Journal of physiology, 2017 - Wiley Online Library
Obstructive sleep apnoea (OSA) is a highly prevalent condition and recognized as a major
public health burden conveying a significant risk of cardiometabolic diseases and mortality …

Metabolic consequences of intermittent hypoxia: relevance to obstructive sleep apnea

LF Drager, JC Jun, VY Polotsky - Best practice & research Clinical …, 2010 - Elsevier
Obstructive sleep apnea (OSA) is recurrent obstruction of the upper airway leading to sleep
fragmentation and intermittent hypoxia (IH) during sleep. There is growing evidence from …

Moderate hypoxia potentiates interleukin-1β production in activated human macrophages

EJ Folco, GK Sukhova, T Quillard, P Libby - Circulation research, 2014 - Am Heart Assoc
Rationale: Inflammation drives atherogenesis. Animal and human studies have implicated
interleukin-1β (IL-1β) in this disease. Moderate hypoxia, a condition that prevails in the …