Genetic alterations in childhood acute lymphoblastic leukemia: interactions with clinical features and treatment response
Simple Summary The latest molecular taxonomy of acute lymphoblastic leukemia (ALL)
comprises> 20 distinct genetic subtypes, each with their own unique clinical and prognostic …
comprises> 20 distinct genetic subtypes, each with their own unique clinical and prognostic …
Epigenetic changes in fibroblasts drive cancer metabolism and differentiation
Genomic changes that drive cancer initiation and progression contribute to the co-evolution
of the adjacent stroma. The nature of the stromal reprogramming involves differential DNA …
of the adjacent stroma. The nature of the stromal reprogramming involves differential DNA …
Differential expression of MUC4, GPR110 and IL2RA defines two groups of CRLF2-rearranged acute lymphoblastic leukemia patients with distinct secondary lesions
T Sadras, SL Heatley, CH Kok, P Dang, KM Galbraith… - Cancer letters, 2017 - Elsevier
Abstract CRLF2-rearrangements (CRLF2-r) occur frequently in Ph-like B-ALL, a high-risk
ALL sub-type characterized by a signaling profile similar to Ph+ ALL, however accumulating …
ALL sub-type characterized by a signaling profile similar to Ph+ ALL, however accumulating …
The recombinome of IKZF1 deletions in B-cell precursor ALL
The occurrence of IKZF1 deletions increases the risk of relapse in patients with B-cell
precursor acute lymphoblastic leukemia (BCPALL)[1, 2]. Therefore, the development of …
precursor acute lymphoblastic leukemia (BCPALL)[1, 2]. Therefore, the development of …
Identification of 17 mRNAs and a miRNA as an integrated prognostic signature for lung squamous cell carcinoma
J Zhang, Z Bing, P Yan, J Tian, X Shi… - The Journal of Gene …, 2019 - Wiley Online Library
Background Gene signatures for predicting the outcome of lung squamous cell carcinoma
(LUSC) have been employed for many years. However, various signatures have been …
(LUSC) have been employed for many years. However, various signatures have been …
IKZF1 Gene in Childhood B-cell Precursor Acute Lymphoblastic Leukemia: Interplay between Genetic Susceptibility and Somatic Abnormalities
SNPs in IKZF1 are associated with inherited susceptibility to B-cell precursor acute
lymphoblastic leukemia (BCP-ALL). Besides, somatic copy number abnormalities (CNA) in …
lymphoblastic leukemia (BCP-ALL). Besides, somatic copy number abnormalities (CNA) in …
[HTML][HTML] IKZF1 deletions with COBL breakpoints are not driven by RAG-mediated recombination events in acute lymphoblastic leukemia
Abstract IKZF1 deletion (ΔIKZF1) is an important predictor of relapse in both childhood and
adult B-cell precursor acute lymphoblastic leukemia (B-ALL). Previously, we revealed that …
adult B-cell precursor acute lymphoblastic leukemia (B-ALL). Previously, we revealed that …
An investigation of methylation pattern changes in the IKZF1 promoter in patients with childhood B-cell acute lymphoblastic leukemia
Background Ikaros family zinc finger 1 (IKZF1) is a transcription factor with an important role
in controlling hematopoietic proliferation and function, particularly lymphoid cell …
in controlling hematopoietic proliferation and function, particularly lymphoid cell …
B-lymphocyte deficiency and recurrent respiratory infections in a 6-month-old female infant with mosaic monosomy 7
K Mai, X Chen, C Wang, S Wu, L Yang, Z Huang… - Immunobiology, 2020 - Elsevier
Monosomy 7 is generally considered as an acquired cytogenetic abnormality within
hematopoietic cells, and indicates an especially high risk of progression to bone marrow …
hematopoietic cells, and indicates an especially high risk of progression to bone marrow …
Identificação de alterações genéticas e sua influência prognóstica na Leucemia Linfóide Aguda Pediátrica no Brasil: uma revisão sistemática
NBG Santos, BMD Nogueira, IC Sousa, MEA Moraes… - 2021 - repositorio.ufc.br
“Brasil” entre os anos 2009 a 2019. Os resultados indicam que a presença da alteração na
expressão dos genes HDAC3, HDAC7, HADC9 e TIMP1 estão associados a taxa de …
expressão dos genes HDAC3, HDAC7, HADC9 e TIMP1 estão associados a taxa de …