Surface charge on biomaterials is emerging as a crucial determinant of regulating cells
responses impacting cells signaling in tissue treatment. The dynamic cell-material …

Chitosan and chitosan oligosaccharides (COS) have been reported to possess various
biomedical properties, including antimicrobial activities, immuno-enhancing effects, and anti …

During cell migration and polarization, numerous signal transduction and cytoskeletal
components self-organize to generate localized protrusions. Although biochemical and …

Antibody charge variants have gained considerable attention in the biotechnology industry
due to their potential influence on stability and biological activity. Subtle differences in the …

Protein nanostructures in living organisms have attracted intense interests in biology and
material science owing to their intriguing abilities to harness ion transportation for …

Abstract Calcium (Ca2+) signaling and dynamic reorganization of the cytoskeleton are
essential processes for the coordination and control of plant cell shape and cell growth …

The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback
mechanisms that regulate signal flow and ensure signal fidelity. A rapid overshoot in insulin …

Prediction of protein localization plays an important role in understanding protein function
and mechanisms. In this paper, we propose a general deep learning-based localization …

Progress through the cell mitotic cycle requires precise timing of the intrinsic molecular steps
and tight coordination with the environmental signals that maintain a cell into the proper …

Lipid-anchored Ras GTPases form transient, spatially segregated nanoclusters on the
plasma membrane that are essential for high-fidelity signal transmission. The lipid …